About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Study Finds Why Folic Acid may Prevent a First Heart Attack, but Not a Second

by Kathy Jones on February 3, 2011 at 8:32 PM
Font : A-A+

 Study Finds Why Folic Acid may Prevent a First Heart Attack, but Not a Second

Research undertaken at Barts and The London School of Medicine and Dentistry may have found an answer to a perplexing medical paradox. This research is published in the current issue of the Public Library of Science.

The paradox is that taking folic acid, a B vitamin, lowers homocysteine in the blood which, epidemiological evidence indicates, should lower the risk of heart attack, but clinical trials of folic acid have not shown the expected benefit.

Advertisement

The explanation is surprisingly simple; lowering homocysteine prevents platelets sticking, which stops blood clots...something aspirin also does, so if people in the trials were already taking aspirin there would be no extra benefit in lowering homocysteine with folic acid. Aspirin was in fact widely used by participants in the trials because they were mainly conducted in patients who had already had a heart attack or other cardiovascular diseases.

Research led by Dr David Wald at the Wolfson Institute of Preventive Medicine at Barts and The London School of Medicine and Dentistry showed that there was a difference in the reduction in heart disease events between the five trials with the lowest aspirin use (60 per cent of the participants took aspirin) and the five trials with the highest use (91 per cent took aspirin). The observed risk reduction was six per cent but it would have been 15 per cent if no one had been taking aspirin. Research was based on 75 epidemiological studies involving about 50,000 participants and clinical trials involving about 40,000 participants.
Advertisement

"The explanation has important implications," said Dr David Wald, the lead author of the paper. "The negative clinical trial evidence should not close the door on folic acid - folic acid may still be of benefit in people who have not had a heart attack because they will generally not be taking aspirin".



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Diet and Oral Health: The Sugary Connection May Become Sour
World AIDS Day 2022 - Equalize!
Test Your Knowledge on Sugar Intake and Oral Health
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Heart Healthy Heart Statins Mitral Valve Prolapse Aortic Valve Stenosis Myelomeningocele Cantaloupes - The Healthy Fruit Pericarditis 

Most Popular on Medindia

Noscaphene (Noscapine) Selfie Addiction Calculator Diaphragmatic Hernia Hearing Loss Calculator Blood Donation - Recipients Pregnancy Confirmation Calculator Iron Intake Calculator Calculate Ideal Weight for Infants Vent Forte (Theophylline) Find a Hospital
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Study Finds Why Folic Acid may Prevent a First Heart Attack, but Not a Second Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests