About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Study: Extra Early Vaccination may Help Reduce Measles Outbreaks

by Rajashri on July 26, 2008 at 3:44 PM
Font : A-A+

 Study: Extra Early Vaccination may Help Reduce Measles Outbreaks

Measles outbreaks in developing countries could be reduced by vaccinating infants at 4.5 months of age in addition to the World Health Organization's recommended routine vaccination at 9 months, a new study has found.

According to researchers, these findings should lead to reconsideration of the policy for vaccination during measles outbreaks and in humanitarian emergencies.

Advertisement

During the first months of life, maternal antibodies protect against measles and infants routinely receive their first vaccination between 9 and 15 months to coincide with when these maternal antibodies are lost.

This vaccination policy was based on children born to naturally infected mothers.

However, measles vaccination campaigns over the past 20-25 years in low-income countries have resulted in many mothers being immunised and transferring only half the maternal measles antibodies as naturally immune mothers.
Advertisement

ikewise, HIV positive mothers transfer a smaller number of antibodies than HIV negative mothers and HIV positive children also lose their protective maternal antibodies early.

As a result, a new group of children now exist who may lose their protection by 3 to 5 months of age and there may well be a need to provide measles vaccination at an earlier age.

An outbreak of measles in Guinea-Bissau in Africa offered Professor Peter Aaby and colleagues a unique opportunity to assess the protective effect of earlier vaccination at 4.5 months.

1333 infants were randomised to receive either measles vaccination at 4.5 months of age (441) or nothing (892). At 9 months of age all children received a measles vaccination.

Researchers collected blood samples to assess levels of maternal antibodies levels against measles at 4.5, 9, and 24 months of age in the early vaccination group and at 9, 18, and 24 months of age in the control group.

They found that early vaccination at 4.5 months of age offered more than 90 percent protection against measles infection and 100 percent protection against measles hospitalisation.

Before the initial vaccination at 4.5 months of age only 28 percent of the children had protective levels of maternal antibodies against measles. After this early vaccination 92 percent had measles antibodies at 9 months of age.

The researchers found that children vaccinated at 4.5 months and 9 months were better protected than those vaccinated only at 9 months.

The monthly incidence of measles was 0.7 percent in the children who received two doses and 3.1 percent in the children who received one dose at 9 months.

"If elimination of measles is planned it will be necessary in Africa to immunise as early as possible for many years", BMJ.com quoted the authors, as saying.

The study was published on BMJ.com today.

Source: ANI
RAS/S
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
Toothache
World AIDS Day 2021 - End Inequalities, End AIDS
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Measles Rashes Symptom Evaluation Top 10 Vaccine Myths Debunked 

Recommended Reading
Measles
Measles is a viral infection with symptoms of fever,and rashes. Measles is prevented by vaccination ...
Mumps
Mumps is a contagious viral infection that typically causes a painful swelling of one or more of ......
Giving an Additional Early Vaccination may Reduce Measles Outbreaks
Outbreaks of measles in developing countries may be reduced by vaccinating infants at 4.5 months of ...
Togo Children to Get Free Jab Against Measles
Togo has launched a major campaign to give free vaccinations against measles to more than one ......
Rashes Symptom Evaluation
The lesions in rashes vary from small skin discolorations to large fluid-filled bullae....
Top 10 Vaccine Myths Debunked
Childhood vaccination has saved many lives, yet lots more has to be done to increase awareness and e...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use