About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Study Exposes Role of Virus Behind Initial Emergence of Cancer

by Medindia Content Team on October 24, 2007 at 3:53 PM
Font : A-A+

Study Exposes Role of Virus Behind Initial Emergence of Cancer

A news study at the University of Pittsburgh School of Medicine has revealed that viruses might contribute to cancer by causing excessive death to normal cells while promoting the growth of surviving cells with cancerous traits.

Led by Preet M. Chaudhary, M.D., Ph.D., professor of medicine, the study has suggested that viruses may act as forces of natural selection by wiping out normal cells that support the replication of viruses and leaving behind those cells that have acquired defects in their circuitry. When this process is repeated over and over, cancer can develop.

Advertisement

Infection with viruses has been linked to many human cancers, including some forms of Hodgkin's and non-Hodgkin's lymphomas, sarcomas and cancers of the throat and liver. Over the years, scientists have proposed a number of mechanisms to explain this link. One commonly held belief is that when a virus infects a cell, its genetic material alters the cell, making it grow uncontrollably, eventually leading to cancer. Some viruses also are thought to promote cancer by causing chronic inflammation.

Dr. Chaudhary's study proposes that viruses also can lead to cancer in a less direct manner. "We believe a separate mechanism may be at play in which a cellular insult, such as infection with a virus, selects a few pre-existing mutated clones of cells, promotes their further growth and multiplication, eventually leading to the emergence of fully cancerous cells. Consequently, similar to the role played by natural selection during evolution, excessive cell death, rather than its absence, may be a defining force that drives the initial emergence of cancer," Dr. Chaudhary said.
Advertisement

He named this model the Phoenix Paradigm in which cancer theoretically arises out of the ashes of dead cells. The paradigm was developed based on a study of cells infected with the Kaposi's sarcoma associated herpesvirus, or KSHV, also known as human herpesvirus 8 (HHV-8).

The research team examined a gene called K13 that activates a pathway previously implicated in cancer development. The researchers found that cells with low K13 expression allowed KSHV to replicate, and these cells subsequently died off. Cells with higher expression of K13 emerged after KSHV replication and showed defective expression of two key proteins that are known to promote cancer.

"This paradigm, if validated by further studies, has implications not only for an improved understanding of the processes involved in cancer, but also for the development of effective strategies for its prevention and treatment," Dr. Chaudhary said.

The study is published by Public Library of Science in the Oct. 24 issue of PLoS ONE.

Source: ANI
LIN/V
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Chicken Pox Shigellosis Cancer and Homeopathy Cancer Facts Cancer 

Recommended Reading
AIDS/HIV - Common Opportunistic Infections
Kaposi sarcoma develops below the skin surfaces or in mucous membranes of mouth, nose or anus and .....
Non-Hodgkins Lymphoma
Non Hodgkins Lymphoma is a cancer that affects the lymph tissues. It is made up of a wide array of ....
Viral ‘Trick’ Caught
University of Pennsylvania School of Medicine scientists have identified a unique mechanism of ......
Tailored Virus That Destroys Brain Tumour Stem Cells
A team of researchers have developed a tailored virus that destroys brain tumour stem cells that ......
Chicken Pox
Chicken pox is an acute and highly contagious viral infection caused by the varicella zoster virus....
Shigellosis
Shigellosis or Bacillary Dysentery is a common cause of gastro-enteritis worldwide and can cause blo...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use