About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Study Explains Why Urinary Tract Infection Recurs in Patients

by Colleen Fleiss on December 15, 2018 at 10:15 PM
Font : A-A+

Study Explains Why Urinary Tract Infection Recurs in Patients

Recurrence of urinary tract infection depends on the bacterial strain, found new study published in journal PLOS Pathogens by Thomas Hannan and Scott Hultgren of Washington University School of Medicine, and colleagues. As noted by the authors, the study suggests that the development of a broad-spectrum vaccine should take into account the genetically diverse pathogens that women encounter in the community.

Many patients suffer from highly recurrent urinary tract infections caused by Escherichia coli, which are genetically diverse bacteria. A better understanding of host-pathogen interactions is urgently needed for effective drug and vaccine development in the era of increasing antibiotic resistance. To address this gap in knowledge, Hannan and Hultgren used a mouse model to compare the effects of two E. coli strains that cause urinary tract infections.

Advertisement


They found that one strain, UTI89, could infect the bladder indefinitely, whereas strain CFT073 was always cleared within eight weeks. After mice had a CFT073 infection and antibiotic treatment, they were protected from a CFT073 challenge infection, but were susceptible to a UTI89 challenge infection. By contrast, mice with a UTI89 infection and antibiotics were susceptible to recurrent urinary tract infections when challenged with either strain.

Depleting T cells, immune cells important for developing protection against infection, prevented mice from clearing their CFT073 infections and made them susceptible to recurrent CFT073 urinary tract infections.
Advertisement

The findings show that infection with one E. coli strain could trigger a protective immune response, while another strain sidestepped this response. According to the authors, the results shed new light on immune responses to urinary tract infections and may be important for drug and vaccine development.

The authors conclude, "This study shows that some bacteria hide from the immune system to cause urinary tract infections again and again."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Can Weight Loss be Achieved by Drinking Water?
Can Exercise Counts Boost Your Life Counts? 
Prevent Hacking of Medical Devices: FDA Sounds Alarm
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cystitis Cystoscopy Urinary Tract Infection Vesico-Ureteric Reflux Causing UTI in Children Hydronephrosis / Antenatal Counseling Diet for Kidney stones Flu Stones in Urinary Tract Interstitial Cystitis Prune Belly Syndrome 

Most Popular on Medindia

Accident and Trauma Care Find a Doctor Blood Donation - Recipients Selfie Addiction Calculator Color Blindness Calculator How to Reduce School Bag Weight - Simple Tips Blood Pressure Calculator Drug - Food Interactions Drug Side Effects Calculator Calculate Ideal Weight for Infants

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use