A study examines the relationship between families with exceptional longevity and cognitive impairment consistent with Alzheimer disease.
The study was done by Stephanie Cosentino, Ph.D., of Columbia University, New York, and colleagues.
The cross-sectional study included a total of 1,870 individuals (1,510 family members and 360 spouse controls) recruited through the Long Life Family Study. The main outcome measure was the prevalence of cognitive impairment based on a diagnostic algorithm validated using the National Alzheimer's Coordinating Center data set.
"Overall, our results appear to be consistent with a delayed onset of disease in long-lived families, such that individuals who are part of exceptionally long-lived families are protected but not later in life," the study concludes.
(JAMA Neurol. Published online May 6, 2013. doi:10.1001/.jamaneurol.2013.1959. Available pre-embargo to the media at http://media.jamanetwork.com.)
Editor's Note: This study was supported by grants from the National Institute on Aging and the American Federation of Aging Research. Please see the articles for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.