About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Study: Discovery Opens Way for Designing TB Shots

by Rukmani Krishna on October 17, 2012 at 12:11 AM
Font : A-A+

 Study: Discovery Opens Way for Designing TB Shots

A study says that specialised immune cells, discovered by Australian researchers, could become instrumental in designing an anti-tuberculosis (TB) vaccine.

The joint study by the Australian universities of Melbourne and Monash has revealed that the highly abundant mucosal associated invariant T cells (MAIT cells), which recognise products of vitamin B synthesis from bacteria and yeast, help activate the immune system.

Advertisement

The research revealed how by-products of bacterial vitamin synthesis, including some derived from folic acid or vitamin B9 and riboflavin or vitamin B2, could be captured by the immune receptor MR1, thus fine-tuning the activity of MAIT cells, the journal Nature reports.

"Humans are unable to make vitamin B and obtain it mostly from diet. Because bacteria can synthesise vitamin B, our immune system uses this as a point of difference to recognise infection," said Lars Kjer-Nielsen from the University of Melbourne, who led the study, according to a Melbourne statement.
Advertisement

"Given the relative abundance of the MAIT cells lining mucosal and other surfaces, such as the intestine, the mouth and lungs, it is quite probable that they play a protective role in many infections from thrush to tuberculosis.

"This is a significant discovery that unravels the long sought target of MAIT cells and their role in immunity to infection," Kjer-Nielsen added.

James McCluskey, professor of microbiology and immunology at Melbourne, said the discovery opened up opportunities for vaccine development and other potential therapeutics.

"This is a major breakthrough in which Australian researchers have beaten many strong research teams around the world, becoming the first to unlock the mystery of what drives a key component of our immune system," he said.

Source: IANS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
COVID Toes
International Yoga Day 2022 - 'Yoga for Humanity'
Wearable Devices Are Now Transforming Depression, Multiple Sclerosis, and Epilepsy Management.
View all
Recommended Reading
News Archive
Date
Category
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Tuberculosis AIDS/HIV Silicosis Screening Tests for Tuberculosis 

Most Popular on Medindia

How to Reduce School Bag Weight - Simple Tips Calculate Ideal Weight for Infants Iron Intake Calculator Drug - Food Interactions Blood - Sugar Chart Drug Interaction Checker Daily Calorie Requirements The Essence of Yoga Color Blindness Calculator Drug Side Effects Calculator

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR