About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Study Examines Effect of Hypothermia in Treating Adults With Severe Meningitis

by Kathy Jones on October 13, 2013 at 9:52 PM
Font : A-A+

 Study Examines Effect of Hypothermia in Treating Adults With Severe Meningitis

A new study led by Bruno Mourvillier from Université Paris Diderot, Sorbonne Paris Cité, Paris, is looking into whether treating comatose patients suffering from bacterial meningitis with hypothermia could help improve functional outcome compared to standard care.

Among adults with bacterial meningitis, the death rate and frequency of neurologic complications are high, indicating the need for new therapeutic approaches. Clinical trials of patients with trauma who were treated with hypothermia have shown a decrease of intracranial pressure, suggesting a potential benefit of this technique in bacterial meningitis, according to background information in the article.

Advertisement

The randomized trial conducted in 49 intensive care units in France between February 2009 and November 2011 assessed 130 patients for eligibility and randomized 98 comatose adults with community acquired bacterial meningitis to the hypothermia group, where patients received a loading dose of 39°F cold saline and were cooled to 90°F to 93°F for 48 hours, or standard care.

The trial was stopped early because of concerns over excess mortality in the hypothermia group (25 of 49 patients [51 percent]) compared with the control group (15 of 49 patients [31 percent]). At 3 months, 86 percent in the hypothermia group compared with 74 percent in the control group had an unfavorable outcome (as gauged via the Glasgow Outcome Scale [a functional assessment inventory]).
Advertisement

"In conclusion, our trial does not support the use of hypothermia in adults with severe meningitis. Moderate hypothermia did not improve outcome in patients with severe bacterial meningitis and may even be harmful. Our results may have important implications for future trials on hypothermia in patients presenting with septic shock or stroke. Careful evaluation of safety issues in these future and ongoing trials are needed," the authors write.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
How to Battle Boredom during COVID
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Meningitis Hypothermia Therapeutic Hypothermia 

Recommended Reading
Meningitis
Meninges are the three layers of membrane that cover the brain and infection of the cerebrospinal .....
Headache / Cephalgia
A headache literally means 'pain in the head'. It is a common complaint that may occur frequently .....
Hypothermia
Hypothermia occurs when body temperature drops to 35 degree Celsius or 95 degree Fahrenheit and belo...
Therapeutic Hypothermia
Therapeutic hypothermia involves the lowering of the body temperature to 350C or less to limit brain...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use