John Hopkins scientists have altered HIV virus in such a way that it loses its ability to suppress the immune system. Their work could remove a major hurdle in HIV vaccine development and lead to new treatments, said the scientists.
Typically, when the body's immune system cells encounter a virus, they send out an alarm by releasing chemicals called interferons to alert the rest of the body to the presence of a viral infection.
When the immune cells encounter HIV, however, they release too many interferons, become overwhelmed and shut down the subsequent virus-fighting response.
The researchers treated HIV with a chemical to remove cholesterol from the viral coat. Then they introduced either the cholesterol-diminished or normal HIV to human immune cells growing in culture dishes, and measured how the cells responded.
The cells exposed to cholesterol-diminished HIV didn't release any initial-response interferons, whereas the cells exposed to normal HIV did.
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The study has been published online September 19 in the journal Blood.
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