Astrocyte proliferation and scar formation are the main factors inhibiting the regeneration and growth of spinal cord axons, following spinal cord injury, leading to motor and sensory function loss below the level of spinal cord injury. Cell transplantation, bioengineering technology, drugs and other methods can reduce voids of injured spinal cord and suppress glial scar formation, but clinical application results show these methods used alone have no obvious effects.
Biphasic Electrical Stimulation: New Hope for Spinal Cord Injury Patients
Biphasic Electrical stimulation (BES, a procedure that doesn't involve the use of chemicals, could prevent cell apoptosis in stem-cell transplant therapy, a new study suggests
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Liang Wu and colleagues from Capital Medical University used rat models of T8 spinal cord contusion, which were subjected to combined transplantation of bone morphogenetic protein-4-induced glial-restricted precursor-derived astrocytes and human recombinant decorin transplantation. This combined transplantation promoted axonal regeneration and growth of injured motor and sensory neurons by inhibiting astrocyte proliferation and glial scar formation, with astrocytes forming a linear arrangement in the contused spinal cord, thus providing axonal regeneration channels. This combined transplantation provides a potential new therapy for experimental research and clinical transformation for the repair of spinal cord injury. These findings were published in the Neural Regeneration Research (Vol. 8, No. 24, 2013).
Source: Eurekalert
Optimal Dose of X-irradiation and Time Window of Local X-ray for Spinal Cord Injury
In the central nervous system, the glial scar is the main inhibitor of axon regeneration and functional recovery.
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