New study has identified 35 genes that predispose people to chronic kidney disease. This finding can increase diagnostic tests and therapy for the debilitating disease that affects around one in ten adults globally. The findings of the study are published in the journal Nature Communications.
"Chronic kidney disease is known for its strong genetic component," said lead researcher Maciej Tomaszewski, Professor at the University of Manchester in the UK.
‘Researchers have identified 35 genes that are associated with chronic kidney disease risk. This discovery may help in the early prediction of the disease even before the development of symptoms.’
"Our limited knowledge of its exact genetic mechanisms partly explains why progress in the development of new diagnostic tests and treatments of chronic kidney disease has been so slow," Tomaszewski added.
Over 100 variants associated with CKD have been uncovered in large-scale genetic studies. The biological mechanisms underlying the genetic susceptibility to CKD have remained elusive, and the progress in clinical translation of the findings from genome-wide association studies has been slow.
The findings were done by using "next-generation RNA sequencing" applied to one of the largest ever collections of human kidneys.
One of the genes mucin-1makes a sticky protein called mucin that coats urinary tubes inside the kidney.
Mutations of this gene have already been found in rare families with inherited kidney failure.
"We hope that early prediction by genetic testing even before the development of symptoms will in the future be the first line of defense against one of the world's top killers," said Professor Fadi Charchar from the Federation University Australia.
"Early detection followed by treatment using kidney-protective medication or avoidance of drugs which can damage the kidneys is the key to healthier kidneys later in life."