Medindia
Advertisement

Stroke Patients Experience Superior Outcomes With Intra-Arterial Treatment

by Bidita Debnath on December 19, 2014 at 9:27 AM

 Stroke Patients Experience Superior Outcomes With Intra-Arterial Treatment
Intra-arterial treatment, also called endovascular or interventional treatment, involves working inside the artery to remove the clot.

Penumbra, Inc., the market leader in intra-arterial stroke treatment, announced that an independent study published online in the New England Journal of Medicine found that intra-arterial stroke treatment, including the company's clot extraction technology, was shown to be significantly more effective than medical management with tissue plasminogen activator (tPA), which is the current standard of care. The findings of this randomized, controlled comparative effectiveness trial of stroke treatment have the potential to change the standard of care and improve functional independence for the 15 million stroke patients worldwide who currently have few treatment options.
Advertisement

In the MR CLEAN (Multicenter Randomized Clinical trial of Endovascular treatment for Acute ischemic stroke in the Netherlands) comparative effectiveness study, intra-arterial treatment improved the rate of good functional outcome by 71 percent over treatment with medical management with tPA alone. Of patients who received intra-arterial treatment, 32.6% achieved a clinically defined positive stroke outcome compared with 19.1% of those who received medical management. Intra-arterial treatment was beneficial for all ages (18+), including the elderly (80+) - a population for whom intervention was previously thought to be risky. The trial began enrolling in 2010 and participating physicians used earlier generation intra-arterial technology. Currently available technology continues to improve upon the baseline set by MR CLEAN.

"Despite being the number one cause of long-term adult disability, stroke has been one of the most undertreated and devastating diseases in the world," said Albert J. Yoo, M.D., director of Acute Stroke Intervention in the Division of Interventional Neuroradiology/Endovascular Neurosurgery at Massachusetts General Hospital, assistant professor at Harvard Medical School and study author of MR CLEAN. "Now that intra-arterial treatment has been proven to provide significant benefits for stroke patients of all ages, we have a golden opportunity to dramatically improve the lives of stroke victims and, at the same time, help reduce costs in our healthcare system by returning patients to functional independence."
Advertisement

MR CLEAN also demonstrated:
  • Intra-arterial treatment was effective for patients with the most common and devastating form of stroke, LVO (large vessel occlusion), for which tPA is less effective.
  • Intra-arterial treatment is effective up to 6 hours after stroke onset vs. 3 to 4.5 hours for tPA.
  • Both treatments were safe, with no differences relating to hemorrhage or mortality.
"With the results of MR CLEAN, we have the needed evidence to support endovascular treatment in the fight against stroke, and the results are truly astounding," said Michael J. Alexander, MD, FACS, Director of the Neurovascular Center, Professor of Neurosurgery at Cedars-Sinai and past president of the Society of NeuroInterventional Surgery. "They show that endovascular treatment can benefit a broad population of patients - not just younger patients as previously thought but older patients as well if treated early."

"The MR CLEAN study results provide evidence to support intra-arterial treatment in the fight against stroke and have the potential to change the standard of care," said Adam Elsesser, chief executive officer, director and founder, Penumbra. "Penumbra is proud to have supported the MR CLEAN trial, and these important results will aid our efforts to improve access to intra-arterial treatment for the millions of stroke patients around the world."

Penumbra provided an unrestricted grant for the trial, and its devices were among those included in the protocol. Companies providing grants had no influence over the trial's design or execution. Penumbra's newest intra-arterial treatment, which was not available at the time MR CLEAN was conducted, is the ACE™, a next generation clot extraction system that uses aspiration alone to engage and remove blood clots causing an acute ischemic stroke. Results with the Penumbra ACE system continue to improve upon the baseline set by MR CLEAN.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
Stroop Effect
Plant-Based Diet may Reduce the Risk of COVID-19
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Bell´s Palsy Diet Lifestyle and Heart Disease Mitral Valve Stenosis And Mitral Valve Replacement Congenital Heart Disease Stress and the Gender Divide Stroke Facts Stroke Hyperventilation Aphasia How to Deal with a Stroke 

Recommended Reading
Pediatric Stroke Triggered by Roller Coaster Rides
An unusual stroke in a 4-year-old boy could have been triggered by riding a couple of roller ......
Role of Neuro-Rehabilitation After Stroke
Neuro-rehabilitation helps hemaparetic stroke patients confronted with loss of motor skills on one ....
Mechanism That Causes Brain Damage Among Stroke Patients Discovered
A mechanism that is linked with brain damage caused after a person suffers from a stroke has been .....
New Gene That Reduces Risk of Stroke Discovered
A gene that protects people against one of the major causes of stroke in young and middle-aged ......
Aphasia
Aphasia is a condition where the patient has a language disorder. The patient has problems with comp...
Congenital Heart Disease
Heart diseases that are present at birth are called “ Congenital heart diseases”....
How to Deal with a Stroke
Stroke is a brain attack, which occurs when the blood supply to the brain is interrupted. It affects...
Hyperventilation
Hyperventilation occurs when a person breathes in excess to the body’s requirement....
Mitral Valve Stenosis And Mitral Valve Replacement
Mitral valve replacement is a surgical heart procedure to correct either the narrowing (stenosis) or...
Stress and the Gender Divide
Stress has become entwined in the current lifestyle of a young working couple and has resulted in th...
Stroke
Stroke can cause permanent disability and it is important to recognize its early warning signs to st...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use