About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Stress Hormones Support Heart Health

by Colleen Fleiss on April 18, 2019 at 9:09 AM
Font : A-A+

Stress Hormones Support Heart Health

Stress hormone receptors known as the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) were found to act in concert to help support heart health, stated scientists at the National Institutes of Health and their collaborators. When the signaling between the two receptors is out of balance, the mice have heart disease. When the signaling between the two receptors is out of balance, the mice have heart disease.

The work, published April 16 in Science Signaling, may lead to the development of therapeutic compounds that help people with an increased risk of a heart attack.

Advertisement


Stress increases risk of dying from heart failure by inducing adrenal glands to make a hormone called cortisol. Cortisol is involved in the fight-or-flight response and binds to GRs and MRs in different tissues of the body to reduce inflammation, among other functions. If the level of cortisol remains too high over a long period of time, common risk factors for heart disease may arise, such as increased cholesterol and glucose in the blood and high blood pressure.

Lead author Robert Oakley, Ph.D., first identified a malfunctioning GR in the 1990s when he was a graduate student working with John Cidlowski, Ph.D., at the University of North Carolina at Chapel Hill. Soon after the discovery, other scientists determined that people with above average amounts of this altered GR had greater risk of heart disease. Based on this finding, Oakley and Cidlowski tested a mouse strain without heart GR in their lab at the National Institute of Environmental Health Sciences (NIEHS), part of NIH. These animals spontaneously developed enlarged hearts leading to heart failure and death. When the team produced a mouse strain missing cardiac MR, the animals' hearts functioned normally.
Advertisement

Oakley and Cidlowski then wondered what would happen if both receptors were missing from heart tissue, so they made another mouse strain that lacked GR and MR. They guessed that these double-knockout mice would have the same or worse heart problems as the mice without GR.

"To our surprise the hearts were resistant to heart disease," Oakley said.

Cidlowski theorized why the double-knockout mice appeared to be protected against heart disease. He said these mice did not have the gene changes that lead to heart failure as seen in mice lacking GR, while simultaneously exhibiting a gain in function of genes that protect the heart. Although the hearts of these mice function normally, they are slightly enlarged compared to the hearts with no MR.

The end goal, however, is treating people with heart disease. Cidlowski said, in the past, when researchers designed synthetic hormones for this task, they made molecules that only worked on one receptor.

"We propose that since GR and MR cooperate, a better approach is to make a drug that works on both receptors simultaneously," Cidlowski said. "It could help patients with heart disease and prevent subsequent heart diseases."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Ways to Manage Stress during COVID-19 Pandemic
Can Adjusting Fatty Acid Intake Improve Mood in Bipolar Disorder Patients?
Insulin Resistance Doubles the Risk of Major Depressive Disorder
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Palpitations And Arrhythmias Stress Relief Through Alternative Medicine Stress and the Gender Divide Andropause / Male Menopause Heart Heart Attack- Lifestyle Risks Healthy Heart Statins Mitral Valve Prolapse Aortic Valve Stenosis 

Recommended Reading
Diet from Crete for Healthy Heart
Mediterranean diets, special attention has been given to the traditional Greek Cretan diet. It ......
Test your Knowledge on Heart Healthy Diet
Heart disease is the leading cause of death - it claims more lives than all forms of cancer ......
Calculate Your Lifetime Risk of Heart Attack
Heart Risk Calculator assesses the lifetime risk for a heart attack and helps in making the right .....
Foods that Can Save Your Heart
Do you enjoy a glass of wine with your meal? If so it's good news for your heart!...
Andropause / Male Menopause
Andropause or male menopause causing low libido in a man is due to decreasing level of male hormones...
Aortic Valve Stenosis
Aortic valve Stenosis is an abnormal narrowing of the c valve. Symptoms include angina, and that of ...
Heart Attack- Lifestyle risks
Heart attack is the death of the heart muscle due to loss of blood supply. Simple guidelines to avoi...
Mitral Valve Prolapse
Mitral Valve Prolapse is a relatively common condition and causes leakage of blood through the valve...
Palpitations And Arrhythmias
Palpitations are unpleasant sensation of one’s own heartbeat....
Statins
Statins are new wonder drugs that are proving to be efficacious, not merely in relieving symptoms bu...
Stress and the Gender Divide
Stress has become entwined in the current lifestyle of a young working couple and has resulted in th...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use