About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Stress, Genetic Risk, Dieting Trigger Anorexia Nervosa

by Bidita Debnath on April 19, 2016 at 2:03 AM
Font : A-A+

 Stress, Genetic Risk, Dieting Trigger Anorexia Nervosa

Anorexia nervosa is an eating disorder, causing people to be obsessive about weight and what they eat, and is incurable. It has a mortality rate of 8 to 15 percent, the highest of any psychiatric disease.

A combination of genetic and environmental risk factors can trigger eating disorders in humans, finds a study conducted in mice, which can lead to prevention and treatment strategies for the fatal disorder.

Advertisement


The findings showed that apart from genetic risks, social stress like isolation and dieting as a result of peer pressure, which is specifically, the desire to be thin could trigger anorexia in adolescents.

"We think that for the first time, we have a mouse model of anorexia that closely resembles the conditions leading up to the disease in humans," said lead researcher Lori Zeltser, associate professor at Columbia University Medical Centre (CUMC) in US.
Advertisement

Adolescent mice with the gene variant -- associated with anorexia and anxiety in mice and humans -- when exposed to both social isolation stress and caloric restriction, were much more likely to avoid eating.

Changes in feeding behaviour did not occur when the environmental variables were imposed during adulthood. Further, when adolescent mice were subjected to either social stress or caloric restriction, but not both, the animals exhibited little change in feeding behaviour.

"Our findings show that having the at-risk genotype alone is not sufficient to cause anorexia-like behaviour, but it confers susceptibility to social stress and dieting, especially during adolescence," Zeltser explained in the paper published online in the journal Translational Psychiatry.

People with anorexia view themselves as being overweight, even when they are underweight. Also, they are relentlessly obsessed about eating, food and weight control. For the study, the team exposed adolescent mice with at least one copy of a variant of the BDNF gene -- associated with anorexia and anxiety in mice and humans -- to social stress and caloric restriction.

The mice were then placed on a calorie-restricted diet, which usually precedes the development of anorexia in adolescent humans. The results revealed that it acted as an onset for eating disorders.

Source: IANS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test  Your Knowledge on Heart
Test Your Knowlege on Genes
Obesity in Teens Make Inroads into Early Atrial Fibrillation
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Diet Pills The Cabbage Diet Zone Diet Anorexia Nervosa Bulimia Nervosa The Macrobiotic Diet Genetics and Stem Cells Primary Amenorrhea Quiz on Anorexia / Bulimia Christianson Syndrome 

Most Popular on Medindia

Iron Intake Calculator Indian Medical Journals Sinopril (2mg) (Lacidipine) Drug - Food Interactions Color Blindness Calculator Nutam (400mg) (Piracetam) Post-Nasal Drip Drug Interaction Checker Accident and Trauma Care Noscaphene (Noscapine)
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Stress, Genetic Risk, Dieting Trigger Anorexia Nervosa Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests