Stopping Osteoporosis Treatment may Have Adverse Effects

by Bidita Debnath on  August 2, 2017 at 11:47 PM Research News
RSS Email Print This Page Comment bookmark
Font : A-A+

Osteoporosis weakens bone and increases risk of bones breaking, and it is the primary cause of bone fractures in the elderly. Patients with osteoporosis have no symptoms until bone fractures occur.
 Stopping Osteoporosis Treatment may Have Adverse Effects
Stopping Osteoporosis Treatment may Have Adverse Effects

Bone loss in this disease reflects an imbalance between the activity of bone-degrading cells called osteoclasts and bone-building cells called osteoblasts. Teriparatide, a recombinant form of parathyroid hormone, is currently the only FDA-approved treatment for osteoporosis that targets bone formation. This medication stimulates osteoblast activity and increases the lifespan of osteoblasts, but whether it also enhances the production of these bone-forming cells is unknown.

Show Full Article


New findings from Henry Kronenberg's lab at Massachusetts General Hospital and Harvard Medical School suggest that while teriperatide treatment does increase the proliferation of osteoblasts, stopping treatment may have adverse effects. A study published this week in the JCI reports that the number of osteoblast precursor cells and their mature descendants increased in mice undergoing teriparatide treatment. When mice were withdrawn from teriparatide treatment, not only did osteoblast proliferation diminish, but the number of newly-formed fat cells, or adipocytes, increased.

These findings suggest that therapies targeting the parathyroid hormone receptor may enhance osteoblast populations by prioritizing osteoblast development over other cell fates, including adipocytes. The findings also offer insights into possible drawbacks of teriparatide therapy, indicating that the long-term consequences of brief treatment periods could outweigh the benefits.

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Recommended Reading

Diabetes Premium Membership Benefits

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive