A new study published in the journal Immunity reveals that a protein called as aryl hydrocarbon receptor (AhR) is able to suppress the severity of inflammation associated with psoriasis, a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. The study reveals that stimulation of this protein could present a new strategy for treating such chronic inflammatory skin disorders.
Although many genetic factors underlying psoriasis have been identified, environmental factors such as components of tobacco smoke could also contribute to the disease. Because AhR is prevalent in skin cells and is known to respond to environmental contaminants such as dioxin, Stockinger suspected that this receptor could play an important role in psoriasis.
"Currently, the focus for therapeutic intervention in psoriasis is on modulating the activity of immune cells," says senior study author Brigitta Stockinger of MRC National Institute for Medical Research. "However, our study suggests that molecules found in skin cells also play an important role in the disease."
"Because available treatments for psoriasis are not always effective, it might be particularly useful to explore combination therapy with drugs directly targeting the immune system together with different ways of stimulating the AhR pathway," Stockinger says. "The focus of our ongoing studies will be to test whether this combination approach might give added improvement to current therapies."