In a breakthrough study, scientists at Johns Hopkins have mapped out a key chemical step involved in blocking enzyme action in heart failure.
The team showed how the enzyme, phosphodiesterase 5, or PDE5A, involved in heart failure, slows down the breakdown of another vital compound called, cyclic guanosine monophosphate (cyclic GMP), which is critical to cell growth and muscle contraction.
Advertisement
They identified a sulfur- and nitrogen-containing molecule, or S-nitrosyl group that chemically alters the enzyme's amino-acid building blocks.
This so-called S-nitrosylation of amino acid cysteine 181 lead to a 25 percent reduction in PDE5A activity, pinpointing how the enzyme's action is suppressed.
![Small Doses of Toxic Gases Protects Mice from Heart Failure]( "Small Doses of Toxic Gases Protects Mice from Heart Failure")
Despite its rotten-egg smell and high toxicity, hydrogen sulfide in small doses helps protect mice from heart failure, according to research published Tuesday on an experimental treatment
"Knowing the molecular make-up and activity of a protein is critical to understanding heart failure because these problem-specific biochemical reactions are magnified in the disease," said senior study investigator Jennifer Van Eyk, Ph.D., a professor at the Johns Hopkins University School of Medicine and its Heart and Vascular Institute.
"Targeted drug therapies can now be developed and tested to work specifically on cysteine 181, to block the PDE5A enzyme, lower the breakdown of cyclic GMP, and potentially stall progression of heart failure and hypertrophy," she added.
The researchers said that their next step is to investigate how PDE5A affects where cyclic GMP is broken down or made, with the goal of determining if the enzyme also controls the known cell pooling of the compound.
The study was presented at the American Heart Association's annual Scientific Sessions in New Orleans.
Source: ANI
SRM
Small Doses of Toxic Gases Protects Mice from Heart Failure
Despite its rotten-egg smell and high toxicity, hydrogen sulfide in small doses helps protect mice from heart failure, according to research published Tuesday on an experimental treatment
Advertisement
"Knowing the molecular make-up and activity of a protein is critical to understanding heart failure because these problem-specific biochemical reactions are magnified in the disease," said senior study investigator Jennifer Van Eyk, Ph.D., a professor at the Johns Hopkins University School of Medicine and its Heart and Vascular Institute.
"Targeted drug therapies can now be developed and tested to work specifically on cysteine 181, to block the PDE5A enzyme, lower the breakdown of cyclic GMP, and potentially stall progression of heart failure and hypertrophy," she added.
The researchers said that their next step is to investigate how PDE5A affects where cyclic GMP is broken down or made, with the goal of determining if the enzyme also controls the known cell pooling of the compound.
The study was presented at the American Heart Association's annual Scientific Sessions in New Orleans.
Source: ANI
SRM
Clinical Trial Shows Promising Results of Gene Therapy for Heart Failure
American scientists behind the phase I clinical trial of gene therapy for heart failure patients.
Advertisement
Advertisement
|
Advertisement
Recommended Readings
Latest Research News
The discovery deepens our understanding of m6A biology and stress granule formation, with implications for neurodegenerative diseases.
Trouble with sleep and the body's clock may increase your risk for Parkinson's, as per a new study.
New study uncovers a link between nocturnal hot flashes and Alzheimer's risk in menopausal women, suggesting a potential biomarker.
Our discovery revealed that a minority of individuals attributed their chronic pain to their brain's involvement.
Relative Energy Deficiency in Sport syndrome is overlooked by athletes and can be worsened by 'sports culture' due to its perceived short-term performance benefits.
