About Careers Internship MedBlog Contact us

Steps to Block Key Enzyme Action in Heart Failure Mapped

by VR Sreeraman on November 13, 2008 at 5:19 PM
 Steps to Block Key Enzyme Action in Heart Failure Mapped

In a breakthrough study, scientists at Johns Hopkins have mapped out a key chemical step involved in blocking enzyme action in heart failure.

The team showed how the enzyme, phosphodiesterase 5, or PDE5A, involved in heart failure, slows down the breakdown of another vital compound called, cyclic guanosine monophosphate (cyclic GMP), which is critical to cell growth and muscle contraction.


They identified a sulfur- and nitrogen-containing molecule, or S-nitrosyl group that chemically alters the enzyme's amino-acid building blocks.

This so-called S-nitrosylation of amino acid cysteine 181 lead to a 25 percent reduction in PDE5A activity, pinpointing how the enzyme's action is suppressed.

"Knowing the molecular make-up and activity of a protein is critical to understanding heart failure because these problem-specific biochemical reactions are magnified in the disease," said senior study investigator Jennifer Van Eyk, Ph.D., a professor at the Johns Hopkins University School of Medicine and its Heart and Vascular Institute.

"Targeted drug therapies can now be developed and tested to work specifically on cysteine 181, to block the PDE5A enzyme, lower the breakdown of cyclic GMP, and potentially stall progression of heart failure and hypertrophy," she added.

The researchers said that their next step is to investigate how PDE5A affects where cyclic GMP is broken down or made, with the goal of determining if the enzyme also controls the known cell pooling of the compound.

The study was presented at the American Heart Association's annual Scientific Sessions in New Orleans.

Source: ANI
Font : A-A+



Recommended Readings

Latest Research News

Insight into Cellular Stress: Mechanisms Behind mRNA Sequestration Revealed
The discovery deepens our understanding of m6A biology and stress granule formation, with implications for neurodegenerative diseases.
Disrupted Circadian Rhythm Elevates the Risk of Parkinson's Disease
Trouble with sleep and the body's clock may increase your risk for Parkinson's, as per a new study.
A Wake-Up Call for Women — Hot Flashes Could Point to Alzheimer's Risk
New study uncovers a link between nocturnal hot flashes and Alzheimer's risk in menopausal women, suggesting a potential biomarker.
Breakthrough Brain-Centered Approach Reduces Chronic Back Pain
Our discovery revealed that a minority of individuals attributed their chronic pain to their brain's involvement.
New Statement to Protect Athletes' Health Published
Relative Energy Deficiency in Sport syndrome is overlooked by athletes and can be worsened by 'sports culture' due to its perceived short-term performance benefits.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
Greetings! How can I assist you?MediBot

Steps to Block Key Enzyme Action in Heart Failure Mapped Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests