About Careers MedBlog Contact us

Stem-Loss in Cancer Therapy Treated With New Discovery

by Rathi Manohar on September 6, 2010 at 9:31 PM
Font : A-A+

 Stem-Loss in Cancer Therapy Treated With New Discovery

Chemotherapy or radiation therapy leads to loss of stem cells that ends in anaemia, appetite and weight loss in cancer patients.

The loss of adult stem cells is particularly dangerous, as they are the ones responsible for making new blood and intestine cells. Scientists have long known that during cancer therapy, the tumour suppressor p53 is activated, which leads cells to stop dividing, go into hibernation and undergo a programmed cell death called apoptosis.


They've also known that a gene called Puma is critical for p53 to initiate the cell death of DNA-damaged cells, reports Nature.

"You can target Puma to prevent p53-mediated depletion of adult stem cells, because a Puma deficiency does not promote the development of cancer," said Yang Xu at UC San Diego.

"If you can suppress Puma function, you can rescue a lot of the adult stem cells that would otherwise be lost after the accumulation of DNA damage such as during cancer therapy," he added.

The team published its findings in this week's advance online issue of the journal Nature Cell Biology.

Source: ANI

Recommended Reading

This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Stem-Loss in Cancer Therapy Treated With New Discovery Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests