About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Stem Cells Capable of Regenerating Bone and Cartilage Identified

by Vishnuprasad on January 21, 2015 at 3:49 PM
Stem Cells Capable of Regenerating Bone and Cartilage Identified

A stem cell capable of regenerating both bone and cartilage has been identified in bone marrow of mice. The discovery by researchers at Columbia University Medical Center (CUMC) is reported today in the online issue of the journal Cell.

The cells, called osteochondroreticular (OCR) stem cells, were discovered by tracking a protein expressed by the cells. Using this marker, the researchers found that OCR cells self-renew and generate key bone and cartilage cells, including osteoblasts and chondrocytes. Researchers also showed that OCR stem cells, when transplanted to a fracture site, contribute to bone repair.

Advertisement

"We are now trying to figure out whether we can persuade these cells to specifically regenerate after injury. If you make a fracture in the mouse, these cells will come alive again, generate both bone and cartilage in the mouse—and repair the fracture. The question is, could this happen in humans," says Siddhartha Mukherjee, MD, PhD, assistant professor of medicine at CUMC and a senior author of the study.

The researchers believe that OCR stem cells will be found in human bone tissue, as mice and humans have similar bone biology. Further study could provide greater understanding of how to prevent and treat osteoporosis, osteoarthritis, or bone fractures.
Advertisement

"Our findings raise the possibility that drugs or other therapies can be developed to stimulate the production of OCR stem cells and improve the body's ability to repair bone injury—a process that declines significantly in old age," says Timothy C. Wang, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine at CUMC, who initiated this research. Previously, Dr. Wang found an analogous stem cell in the intestinal tract and observed that it was also abundant in the bone.

"These cells are particularly active during development, but they also increase in number in adulthood after bone injury," says Gerard Karsenty, MD, PhD, the Paul A. Marks Professor of Genetics and Development, chair of the Department of Genetics & Development, and a member of the research team.

The study also showed that the adult OCRs are distinct from mesenchymal stem cells (MSCs), which play a role in bone generation during development and adulthood. Researchers presumed that MSCs were the origin of all bone, cartilage, and fat, but recent studies have shown that these cells do not generate young bone and cartilage. The CUMC study suggests that OCR stem cells actually fill this function and that both OCR stems cells and MSCs contribute to bone maintenance and repair in adults.

The researchers also suspect that OCR cells may play a role in soft tissue cancers.

The authors declare no financial or other conflicts of interest.

The study was funded by grants from the National Institutes of Health (5U54 CA126513, R01 RHL115145A, AR056246, and EB006834), the Robert Carroll and Jane Chace Carroll Laboratories, the American Cancer Society, the NH&MRC and Menzies Foundation, Cancer Council SA's Beat Cancer Project on behalf of its donors and the State Government of South Australia through the Department of Health, Gastroenterological Society of Australia, the American Gastroenterological Association, the American Association for Cancer Research, the Royal Australasian College of Physicians, and the Columbia University Ines Mandl Postdoctoral research fellowship.

Columbia University Medical Center provides international leadership in basic, preclinical, and clinical research; medical and health sciences education; and patient care. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, public health professionals, dentists, and nurses at the College of Physicians and Surgeons, the Mailman School of Public Health, the College of Dental Medicine, the School of Nursing, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions.

Columbia University Medical Center is home to the largest medical research enterprise in New York City and State and one of the largest faculty medical practices in the Northeast.



Source: Medindia
Font : A-A+

Advertisement

Advertisement
Advertisement

Recommended Readings

Latest Genetics & Stem Cells News

Gene Therapy Breaks Up New Dawn for Beta Thalassemia
Groundbreaking gene therapy for genetic beta thalassemia is now accessible as a treatment to a patient post-FDA approval.
Scientists Uncover Stem Cells in the Thymus for the First Time
Thymic stem cells actively participate in their environment by generating extracellular matrix proteins, essentially forming their own support system.
First Allogenic Stem Cell Transplant
Scientists aspire to utilize stem cell transplantation for pediatric patients grappling with blood-related conditions like aplastic anemia, and thalassemia.
Scientists Accomplish Complete Genome Sequencing of Y Chromosome
Researchers have sequenced male Y chromosomes, yielding a comprehensive blueprint of the entire human chromosome collection.
Cell Therapy for Cornea Damage Addressed by Patient's Own Stem Cells
CALEC (Cultivated autologous limbal epithelial cells) procedure for stem cell transplant in eye procedures is safe and feasible, showing improved corneal surfaces or vision.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
MediBotMediBot
Greetings! How can I assist you?MediBot
×

Stem Cells Capable of Regenerating Bone and Cartilage Identified Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests