A new study has now been conducted to examine the safety of transendocranial stem cell injection with autologous mesenchymal stem cells in patients with ischemic cardiomyopathy.
An effective proregenerative treatment for ischemic cardiomyopathy would address a major unmet need for many patients. An unresolved issue is whether mesenchymal stem cells have similar safety and possibly greater efficacy than bone marrow mononuclear cells, according to background information in the article.
Bone Marrow Cells are the Answer to Avoid Rejection
Scientists from Iowa and Iran have used cells from mice and have discovered a new strategy for making embryonic stem cell transplants less likely to be rejected by a recipient's immune system.
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The included 65 patients with ischemic cardiomyopathy and compared injection of mesenchymal stem cells (n=19) with placebo (n = 11) and bone marrow mononuclear cells (n = 19) with placebo (n = 10), with 1 year of follow-up. The primary measured outcome was treatment-emergent 30-day serious adverse event rate defined as a composite of death, heart attack, stroke, hospitalization for worsening heart failure, perforation (rupture), tamponade (compression of the heart due to collection of blood or fluid), or sustained ventricular arrhythmias.
No patient had treatment emergent-serious adverse event at day 30. Exploratory analyses of 1-year incidence of serious adverse events was 31.6 percent for mesenchymal stem cells, 31.6 percent for bone marrow cells, and 38.1 percent for placebo. Over 1 year, the Minnesota Living with Heart Failure score (a measure of quality of life) improved with mesenchymal stem cells and with bone marrow cells but not with placebo. The 6-minute walk distance increased with mesenchymal stem cells only.
"These results provide the basis for larger studies to provide definitive assessment of safety and to assess efficacy of this new therapeutic approach," the authors write.
Source: Eurekalert
"These results provide the basis for larger studies to provide definitive assessment of safety and to assess efficacy of this new therapeutic approach," the authors write.
Source: Eurekalert
Researchers Use Bone Marrow Cells in Bladder Regeneration
A new study reports on how a new approach to bladder regeneration is capitalizing on the potential of two distinct cell populations harvested from a patient's healthy bone marrow.
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 Umbilical Cord Cells More Effective in Repairing Damaged Heart Than Bone Marrow CellsCells extracted from umbilical cord, also known as Human Umbilical Cord PeriVascular Cells, were more effective in restoring heart function following acute myocardial infarction. | Advertisement
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