About Careers Internship MedBlog Contact us

Statins may Help to Prevent Miscarriages

by VR Sreeraman on October 12, 2008 at 1:36 PM
 Statins may Help to Prevent Miscarriages

Statins may help in preventing miscarriages in women suffering from pregnancy complications caused by antiphospholipid syndrome (APS), according to researchers at Hospital for Special Surgery.

APS is characterised by the production of antibodies directed at phospholipids, the main components of cell membranes.


While in low risk pregnancies, APS is linked with a nine-fold increase in miscarriage; there is a 90 percent risk of miscarriage associated with APS in case of high-risk pregnancies (women who have had at least three prior losses).

"Statins may work as a treatment for women with APS-induced pregnancy complications. They are drugs that have been shown to be very safe. There are a lot of women who continue to take statins through pregnancy and the drugs have not been shown to produce birth defects," said Guillermina Girardi, Ph.D., associate scientist at Hospital for Special Surgery in New York, who is lead author of the study.

Statins do not increase the risk of bleeding like anticoagulants, which is the current treatment for patients with APS.

The researchers examined the white blood cells from mice that had APS and discovered that these cells expressed certain receptors called PAR2 (protease-activated receptor 2). The receptor, when stimulated, led to the activation of white blood cells that attacked the placenta and hurt the foetus. The researchers inhibited white blood cell activation by using an antibody that blocks tissue factor interaction with PAR-2.

It was found that statins not only downregulate tissue factor, but they also downregulate PAR-2 on white blood cells, making the cells less sensitive.

Thus, the researchers injected statins into mice with APS and found that these drugs could prevent white blood cell activation and protect pregnancies.

During pregnancy, women are usually advised to discontinue most medications, including statins, but Girardi said that no foetal defects have been reported in women who have continued to use statins while pregnant.

The researchers said that careful studies should be conducted to confirm the safety of statins in pregnancy in humans.

"Women that are antiphospholipid antibody positive and have a history of previous miscarriages are a good group to perform a clinical trial," said Girardi.

This study could also have implications for other conditions.

"The study reveals a relationship between tissue factor and PAR2 in inflammation that could have implications for understanding chronic inflammatory conditions such as rheumatoid arthritis," he said.

By finding a way to manipulate tissue factor and PAR2, researchers could lead to treatments for diseases like sepsis, atherosclerosis, Cohn's disease, and lupus.

The study is published in the latest issue of the Journal of Clinical Investigation.

Source: ANI
Font : A-A+



Recommended Readings

Latest Women Health News

Reduced Sleep & Activity During Pregnancy Linked to Premature Birth Risk
A higher risk of preterm birth was found to be associated with inadequate sleep and lower physical activity during pregnancy.
Birth Control Pill Pause-Period Steers Mood Dips in Women
During the 7 pill-free days in contraception, women experience anxiety and mental issues similar to menstrual mood swings.
No Link Found Between Four Novel Receptors in Endometrial Cancer and PCOS
In the new study, it remains uncertain if the increased expression of the IGF1 gene in PCOS plays a role in elevating the risk of endometrial cancer.
Obese Women are Prone To Higher Menopause Symptoms
Obese women experience increased severity of menopausal symptoms and reduced effectiveness and relief from hormonal therapy.
Why Women Participate Less in Cardiovascular Rehabilitation?
Cardiovascular rehabilitation, which lowers mortality and readmission rates, is underutilized and less effective in women than in men.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
Greetings! How can I assist you?MediBot

Statins may Help to Prevent Miscarriages Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests