About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Statins may Cut Parkinson's Disease Risk

by Sheela Philomena on March 13, 2012 at 1:08 PM
Font : A-A+

 Statins may Cut Parkinson's Disease Risk

Regular use of cholesterol-lowering statin drugs may lower risk of developing Parkinson's disease, shows study published in Archives of Neurology.

Statins are one of the most prescribed classes of drugs in the United States and some researchers have hypothesized that the anti-inflammatory and immunomodulating effects of these medications may be neuroprotective. However, statins also may have unfavorable effects on lowering the level of plasma coenzyme Q10, which may be neuroprotective in patients with Parkinson disease (PD), the researchers write in their study background.

Advertisement

Xiang Gao, M.D., Ph.D., of Brigham and Women's Hospital and Harvard School of Public Health, Boston, and colleagues conducted a prospective study that included 38,192 men and 90,874 women participating in the Health Professional Follow-up study and the Nurses' Health study.

During 12 years of follow-up from 1994 to 2006, researchers documented 644 incident PD cases (338 in women and 306 in men).

"In summary, we observed an association between regular use of statins and lower risk of developing PD, particularly among younger patients," the researchers comment. "However, our results should be interpreted with caution because only approximately 70 percent of users of cholesterol-lowering drugs at baseline were actual statin users. Further, the results were only marginally significant and could be due to chance."
Advertisement

Researchers note that because they classified the use of any cholesterol-lowering drugs before 2000 as statin use, misclassification was inevitably introduced. They also did not collect information on the use of specific statins, which could have different effects on the central nervous system.

When researchers did observe a significant interaction between statin use and age in relation to PD risk it was among study participants younger than 60 years at the start of follow-up, not among those participants who were older.

The authors note that not only have epidemiologic studies produced mixed results on statin use and PD risk, but statins also may have unfavorable effects on the central nervous system.

"In contrast with use of ibuprofen, which has been consistently found to be inversely associated with PD risk in these cohorts as well as in other longitudinal studies, the overall epidemiological evidence relating stain use to PD risk remains unconvincing," the authors conclude. "Given the potential adverse effects of statins, further prospective observational studies are needed to explore the potential effects of different subtypes of statin on risk of PD and other neurodegenerative diseases."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
World Disability Day 2022 - The Role of Innovative Transformation
Diet and Oral Health: The Sugary Connection May Become Sour
World AIDS Day 2022 - Equalize!
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cholesterol Cholesterol - The Enigma Chemical Statins Nutritional Management of Parkinsons disease 

Most Popular on Medindia

Accident and Trauma Care Pregnancy Confirmation Calculator Blood Pressure Calculator Drug - Food Interactions Nutam (400mg) (Piracetam) Find a Doctor Turmeric Powder - Health Benefits, Uses & Side Effects Blood - Sugar Chart Hearing Loss Calculator Find a Hospital
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Statins may Cut Parkinson's Disease Risk Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests