About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Sperm Stem Cells Help Better Understand Infertility and Certain Cancers in Men

by Hannah Joy on October 7, 2017 at 11:12 AM
Font : A-A+

Sperm Stem Cells Help Better Understand Infertility and Certain Cancers in Men

A new light has been shed on the process involved in the development of human sperm stem cells, which helps to understand male infertility and risk of developing certain cancers, reveals a new study.

The new research was from scientists at Huntsman Cancer Institute (HCI) at the University of Utah and collaborators at University of Utah Health (U of U Health). This is the first study to characterize the changes human sperm stem cells undergo as they mature. The results have implications for understanding male infertility as well as cancer development and were published in the journal Cell Stem Cell.

Advertisement


Previous studies of sperm stem cells have been limited to model systems, including mice. But this first study of developing human sperm stem cells revealed this process was much more complex in humans than had been previously understood. Using genome analysis tools, scientists outlined the multistage process that sperm stem cells undergo during their normal development.

"This information yields new insights into how sperm stem cells function and develop under normal circumstances," says the study's lead author Bradley Cairns, PhD, senior director of basic science at HCI and professor and chair of oncological sciences at the U of U.
Advertisement

"We have built a very important framework we can now use to help us understand what happens when things go wrong, resulting in issues like infertility and cancer in men."

In the study, scientists examined all of the genes that turn 'on' or 'off' in any given cell during normal development. Using single cell RNA sequencing analysis, the Cairns lab profiled cells individually, establishing the gene expression profile in human sperm stem cells.

Their findings outlined four distinct cellular phases of sperm stem cells maturation, revealing how the stem cells progress from a "quiescent" state, to a "proliferation" state during which stem cells divide, to a final "differentiation" state when stem cells mature to become sperm.

Specifically, the data reveal distinct transitions in factors that influence the different cellular states including cell cycle regulators, transcription factors, and signaling factors.

"Working with my patients with infertility, I have seen how devastating this diagnosis can be," says co-author and reproductive urologist James Hotaling, MD, also an assistant professor of surgery at U of U Health. "This study will help us understand what causes infertility in some cases."

The results may also have implications for understanding how some cancers arise. Men with infertility are known to be at higher risk for certain cancers including testicular and prostate cancers.

"Our study sheds new light on how genes normally function in sperm stem cells," says Cairns.

"The next steps will be to use this knowledge to better understand what changes happen when sperm stem cells don't develop normally and instead convert into cancer cells."

The authors believe the results of the study could lead to better tools for diagnosing and treating patients with male infertility, as well as uncovering the complicated genetic changes that underlie cancers associated with male infertility.

Cairns and Hotaling collaborated with first author Jingtao Guo and co-authors Edward Grow, Chongil Yi, Patrick Murphy, Candice Wike, and Douglas Carrell. The research is titled "Transcription, Signaling and Metabolic Transitions During Human Spermatogonial Stem Cell Differentiation".



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Stem Cells - Cord Blood Genetics of Male Infertility In Vitro Fertilization (IVF) Infertility Stem Cells - Fundamentals Vaginitis Parkinsons Disease Surgical Treatment Egg Donation Artificial Insemination Polycystic Ovarian Syndrome 

Recommended Reading
Preserving Sperm Stem Cells - New Technique to Prevent Infertility in Boys With Cancer
A new technique to preserve the sperm stem cells could be promising in maintaining the fertility of ...
Cancer Drug Helps Prevent Infertility in Cancer Patients
Cancer treatments like radiation and chemotherapy often kill sperm stem cells, male reproduction ......
French Lab Claims Breakthrough With the World's First Lab-Grown Human Sperm Cells
Research paves way for innovative therapies to preserve and restore male fertility, a major issue .....
Artificial Insemination
Artificial Insemination is a medical procedure usually used to treat infertility. In this procedure,...
Egg Donation
The term ‘Egg Donation’ is commonly used to refer to the contribution of her eggs by a woman to anot...
Genetics of Male Infertility
Encyclopedia section of medindia briefs you about the Genetics of Male Infertility...
In Vitro Fertilization (IVF)
Encyclopedia section of medindia gives a brief introduction to infertility and reproduction...
Infertility
Infertility is a condition wherein couples fail to achieve pregnancy or if the woman has been unable...
Polycystic Ovarian Syndrome
Polycystic ovarian syndrome is the most common hormonal disorder among women of reproductive age an...
Stem Cells - Fundamentals
Encyclopedia section of medindia gives general info about Stem Cells...
Stem Cells - Cord Blood
Encyclopedia section of medindia gives general info about Cord Blood...
Vaginitis
Vaginal infection or vaginitis occurs due to an overgrowth of bacteria or yeast or trichomoniasis ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use