Microglial Cells in Negative Mood

"The study showed that animals feel sick and uneasy when we activate the microglial cells. We demonstrate that two signal molecules, interleukin-6, and prostaglandin E2, are particularly important in these processes. It's not surprising that these signal substances are central, but we were a bit surprised that it is the microglial cells that release these molecules", says David Engblom, a professor in the Department of Biomedical and Clinical Sciences (BKV) at Linköping University.

Using a specific technique called chemogenetics, scientists were able to activate the microglial cells when the mice models were being kept in a certain type of surroundings. Avoidance behavior was seen in the mice, showing that the animals disliked the experience.

Also, the mice demonstrated symptoms of negative mood where it became less interested in a sweet solution, which they normally find very tempting.

Inhibition of the microglial cells, that is, when the microglia were not available for activation, the mice did not feel poorly, even when they had inflammation. This depicts an important link between the immune system and mood, in the presence of microglia cells.

"Our results show that the activation of microglial cells is sufficient to create aversion and negative mood in mice. It's natural to suggest that similar processes take place in several human diseases. It's not unlikely that activated microglia contribute to the discomfort and depressed mood in people with inflammatory and neurological diseases", says, David Engblom.

However further research is needed to demonstrate the microglial biological mechanism in humans, that may aid in formulating ways to inhibit this pathway and reduce symptoms of depression.



Source: Medindia