Smart Platform Helps in Heart Disease Treatment

by Colleen Fleiss on  December 5, 2019 at 12:12 AM Heart Disease News
RSS Email Print This Page Comment bookmark
Font : A-A+

Rapid endothelialization poses challenges, however, when using existing synthetic biomaterials, due to their static properties. Such materials cannot offer dynamic, on-demand means for manipulating specific vascular endothelial cell functions at different stages of endothelium remodeling. Remodeling the endothelium - i.e., forming a confluent vascular endothelial cell monolayer on the lumen - plays a vital role in this process.
Smart Platform Helps in Heart Disease Treatment
Smart Platform Helps in Heart Disease Treatment

The researchers first prepared a bilayer platform with programmable surface topographies using a shape-memory polymer and gold nanorods acting as a photothermal agent. The bilayer platform allowed on-demand manipulation of vascular endothelial cell functions, thus meeting the requirements of endothelium remodeling.

Show Full Article


During the endothelialization process of native blood vessels, vascular endothelial cells and progenitor cells are first recruited to regeneration sites. This is followed by the adhesion and spreading of the vascular endothelial cells to form a confluent vascular endothelial cell monolayer. In the human body, such a process is implemented through extracellular matrix (ECM)-mediated stepwise modulation of vascular endothelial cell functions at different stages.

"The new platform possesses originally stable anisotropic microgroove array topography. This topography can significantly direct cell polarization and thereby enhance the collective migration of vascular endothelial cells," said ZHAO Qilong, first author of the study.

Upon 10 s of near-infrared (NIR) irradiation, the heat generated on the bottom layer induced the surface topographies of the platform to change from their original anisotropic microgroove array to a permanent isotropic micropillar array.

The focal adhesion and spreading of vascular endothelial cells were subsequently promoted at the later stage of endothelialization by the platform after the topographies were changed. The remote-controlled "smart" platform promoted different functions of vascular endothelial cells in turn, thus mimicking dynamic ECM-mediated effects throughout the endothelialization process for the first time using synthetic biomaterials.

"Traditionally, biomaterials and tissue engineering scaffolds offer suitable platforms to support cell attachment and ingrowth. We aim to develop biomaterials with dynamic properties to actively modulate different cell functions in specific spatiotemporal manners, just like the native ECM in our bodies," said Dr. DU Xuemin from SIAT.

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Recommended Reading

Premium Membership Benefits

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive