Medindia
Advertisement

Skin can be 'Infection Free' With Fat

by Himabindu Venkatakrishnan on January 2, 2015 at 6:01 PM

 Skin can be 'Infection Free' With Fat
Fat cells below the skin provides protection from bacteria, proving that all the fat may not be bad after all.

Richard Gallo, MD, PhD, professor and chief of dermatology at the University of California, along with his colleagues, uncovered a previously unknown role for dermal fat cells, known as adipocytes: They produce antimicrobial peptides that help fend off invading bacteria and other pathogens.
Advertisement

Gallo said that though it was thought that once the skin barrier was broken, it was entirely the responsibility of circulating (white) blood cells like neutrophils and macrophages to protect us from getting sepsis.

But it took time to recruit the cells (to the wound site). And they have now shown that the fat stem cells were responsible for protecting us, which was totally unexpected. It was not known that adipocytes could produce antimicrobials, let alone that made almost as much as a neutrophil, he added.
Advertisement

Prior published work out of the Gallo lab had observed S. aureus in the fat layer of the skin, so researchers looked to see if the subcutaneous fat played a role in preventing skin infections.

Ling Zhang, PhD, the first author of the paper, exposed mice to S. aureus and within hours detected a major increase in both the number and size of fat cells at the site of infection. More importantly, these fat cells produced high levels of an antimicrobial peptide (AMP) called cathelicidin antimicrobial peptide or CAMP. AMPs are molecules used by the innate immune response to directly kill invasive bacteria, viruses, fungi and other pathogens.

The scientists confirmed their findings by analyzing S. aureus infections in mice unable to either effectively produce adipocytes or whose fat cells did not express sufficient antimicrobial peptides in general and CAMP in particular. In all cases, they found the mice suffered more frequent and severe infections.

Further tests confirmed that human adipocytes also produce cathelicidin, suggesting the immune response is similar in both rodents and humans. Interestingly, obese subjects were observed to have more CAMP in their blood than subjects of normal weight.

The potential clinical applications of the findings will require further study, said Gallo.

"Defective AMP production by mature adipocytes can occur due to obesity or insulin resistance, resulting in greater susceptibility to infection, but too much cathelicidin may provoke an unhealthy inflammatory response. The key is that we now know this part of the immune response puzzle. It opens fantastic new options for study," said the scientists.

The paper is published in Science.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
Stroop Effect
Plant-Based Diet may Reduce the Risk of COVID-19
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cholesterol Boils / Skin Abscess Diet Lifestyle and Heart Disease Pityriasis rosea Cholesterol - The Enigma Chemical Liposuction Pemphigus Hives Scleroderma Vitiligo 

Recommended Reading
Exhale Out Your Excess Fat Through Your Lungs
Did you know that when you lose weight most of it is exhaled out through your lungs? A new study ......
Low Saturated Fat and Low Cholesterol Diet
To avoid obesity we must consciously control the quantity and the quality of fat that we eat and ......
Fat Burning Fruits
There are many fat-burning fruits. You can eat a fat-burning diet with the help of these belly ......
Could Seaweed Help Cut Fat in Your Chocolate?
Low-fat chocolate on your mind? Researchers seem to have developed just that. Read about a new ......
Boils / Skin Abscess
Encyclopedia section of medindia gives general info about Boils / Skin Abscess ...
Cholesterol
Cholesterol is produced by the body (liver) and is essential for normal body functioning....
Cholesterol - The Enigma Chemical
The word 'Cholesterol' rings danger bells as soon as it is mentioned. This important chemical is im...
Hives
Hives or Urticaria are allergic skin reaction that appear suddenly in clusters or as single bumps on...
Liposuction
Liposuction is a cosmetic procedure, which is used to suck out the excess or abnormal fat deposition...
Pemphigus
Pemphigus is a rare group of autoimmune diseases that affect the skin and mucous membranes causing b...
Pityriasis Rosea
Pityriasis rosea is a common skin disease that is not contagious. It manifests as oval-shaped, pink ...
Scleroderma
Scleroderma or CREST syndrome is a chronic, auto immune disease which manifests as thick, dry, fibro...
Vitiligo
Vitiligo is a skin disease characterized by patches of unpigmented skin. Vitiligo is usually slowly ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use