The Simvastatin and Ezetimibe in Aortic Stenosis (SEAS)
study was designed to examine the effects of lowering low-density lipoprotein
(LDL) cholesterol in patients with aortic stenosis and involved 1,873 patients
with mild to moderate aortic stenosis
All patients were assigned to randomly receive
simvastatin 40 mg QD and ezetimibe 10 mg QD or equivalent dose of placebo.
therapy was found to lower LDL or bad cholesterol and thus reduce risk of CAD,
but it was not able to slow down the progression of the disease.