About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Simple Technique to Distinguish Between Stem Cells and Progenitors

by VR Sreeraman on August 27, 2007 at 3:05 PM
Font : A-A+

Simple Technique to Distinguish Between Stem Cells and Progenitors

Johns Hopkins scientists have discovered a simple technique to distinguish between "true" neural stem cells and similar but less potent versions.

The new development is a study in which the scientists worked with embryonic mouse brains. It may simplify the isolation of stem cells not only from brain, but also other body tissues, say the researchers.

Advertisement

The researchers say that they have identified a specific protein "signal", which appears to prevent neural stem cells from taking their first step towards becoming neurons. They say that this sort of protein might be used to rebuild a damaged nervous system.

"Stem cells don't instantly convert into functional adult tissue. They undergo a stepwise maturation where they gradually shed their stem cell properties," Nature magazine quoted study author Dr. Nicholas Gaiano, assistant professor at the Institute for Cell Engineering, as saying.
Advertisement

The first step turns stem cells into "progenitor" cells by dictating the mechanism through which signals downstream of the Notch protein, which regulates stem cells in many different tissues, are transmitted. One well-known target of Notch is a protein called CBF1.

In order to study Notch signalling further, Dr. Gaiano and his colleagues created genetically engineered mouse embryos that glow green when CBF1 is turned on.

The researchers found that during brain development some of the brain cells, generally thought to be neural stem cells, stopped glowing. It was an indication that the CBF1 protein was no longer active in them. A closer look revealed that the cells that went dark were in fact no longer true neural stem cells, which could form all major brain cell types, but instead had aged into progenitor cells, which formed mostly neurons.

The researchers then knocked out the CBF1 protein in neural stem cells so as to test whether it was the critical switch. They found that the knockout got the stem cells to rapidly convert to progenitor cells. "However, if we activated the CBF1 protein in progenitor cells we couldn't get them to shift back into stem cells. So whatever happens biochemically once CBF1 is turned off seems to create a one-way street," says Dr. Gaiano.

In another study, Dr. Gaiano and his colleagues have also found that CBF1 signalling may play the same role in blood stem cells, indicated that the new discovery might be a general "switch" distinguishing stem cells from progenitors in many different tissues.

Source: ANI
LIN/J
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
How to Battle Boredom during COVID
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Stem Cells - Cord Blood Stem Cells - Fundamentals Parkinsons Disease Surgical Treatment Genetics and Stem Cells Bone Marrow Transplantation Tissue Engineering and Regenerative Medicine Stem Cells Stem Cell Therapy 

Recommended Reading
Stem Cells - Fundamentals
Encyclopedia section of medindia gives general info about Stem Cells...
Bone Marrow Transplantation
Preferred Term is Hematopoietic stem cell transplantation. In this stem cell from bone marrow are in...
Stem Cell Therapy
Stem cell therapy or regenerative medicine uses undifferentiated cells for the treatment of conditio...
Stem Cells - Cord Blood
Encyclopedia section of medindia gives general info about Cord Blood...
Tissue Engineering and Regenerative Medicine
This new field is an amalgamation of biology, medicine and engineering, and is believed to have mind...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use