Recovery for a wide variety of stroke patients can be ensured by the remote ischemic limb conditioning method that causes the inflammatory monocytes to increase in number.
Cutting off and then restoring blood supply to a limb following a stroke reduces tissue damage and swelling and improves functional recovery, according to a new study in mice published in JNeurosci. The simple, noninvasive technique could be developed into a treatment for stroke patients of varying severity.
Genes may Influence Post-stroke Recovery
Post-stroke recovery is estimated by genetic variants, said new study. Ischemic stroke is the most common form of stroke, in which a blood clot causes a lack of oxygen in a region of the brain.
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‘Simple and non-invasive technique of using a blood pressure cuff to cut off then restore blood supply to a limb reduces brain tissue damage, swelling, and improves functional recovery.’
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Remote ischemic limb conditioning utilizes a blood pressure cuff and has been shown to aide in stroke recovery, potentially by affecting monocytes. Monocytes are a type of white blood cell involved in immune responses that can either reduce or promote inflammation, which is necessary in the tissue recovery process.
Sunghee Cho and colleagues at Burke Neurological Institute treated mice that experienced a stroke with remote ischemic limb conditioning and tested the monocyte levels in their blood. The research team found that the ratio of inflammatory to non-inflammatory monocytes circulating in the blood increased, resulting in more available inflammatory cells.
![Gene Vital for Post-stroke Recovery Identified]( "Gene Vital for Post-stroke Recovery Identified")
Having certain specific variants of the PATJ gene predisposes to worse recovery from ischemic stroke, said researchers.
Surprisingly, the increase in circulating inflammatory cells was associated with reduced brain tissue damage and swelling and improved motor function. The symptoms improved for both moderate and severe strokes, indicating the potential for wide application as a stroke treatment.
Source: Eurekalert
Gene Vital for Post-stroke Recovery Identified
Having certain specific variants of the PATJ gene predisposes to worse recovery from ischemic stroke, said researchers.
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Surprisingly, the increase in circulating inflammatory cells was associated with reduced brain tissue damage and swelling and improved motor function. The symptoms improved for both moderate and severe strokes, indicating the potential for wide application as a stroke treatment.
Source: Eurekalert
Cutting Off Sensory Signals Can Aid in Stroke Recovery
If neuronal signaling to one area gets cut off neighboring functions will spread into that unused area.
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 Antidepressant Doesn't Seem to Help Stroke RecoveryCommon medication prescribed for depression was assumed to decrease the risk of stroke. But, the recent study proved that there is no such benefit | Advertisement
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