Medindia
Advertisement

Simple Blood Test to Improve the Early Lung Cancer Detection

by Colleen Fleiss on February 13, 2019 at 4:17 AM
Font : A-A+

Simple Blood Test to Improve the Early Lung Cancer Detection

In mice, pre-cancerous lung tests can be analyzed using blood-based tests, revealed research led by scientists at the Medical Research Council (MRC) Toxicology Unit. The findings of the study are published in the journal Disease Models and Mechanism.

Lung cancer is the number one cause of cancer-related death around the world, partly due to the difficulties in detecting the disease at an early stage. By the time lung cancer is diagnosed, it has often spread to other parts of the body making it much more difficult to treat, which is why improved diagnosis at an earlier stage is key to beating the disease.

Advertisement


The scientists at the MRC Toxicology Unit, part of the University of Cambridge, alongside scientists at the University of Leicester, used mice with a mutation in a gene called KRAS to model the pre-cancerous stages of lung cancer. The researchers took regular computed tomography (CT) scans to monitor the development of small pre-cancerous lung tumours in the mice. To determine whether circulating DNA could be used to detect the tumours before they became malignant, blood samples were taken along with the CT scans at different time intervals.

The team found that the mice developing cancerous lung tumours had higher levels of circulating DNA compared with healthy mice, and that the levels of DNA released by the cancerous tumours into the blood of the mice correlated with the size of the tumours seen on the CT scans. The circulating DNA was then analysed for the presence of the precise KRAS mutation that caused the tumours to develop. The researchers found that, significantly, in later stages of tumour development where tumours were still pre-cancerous, the KRAS mutation could still be detected in circulating DNA.
Advertisement

"This observation is exciting because it suggests that tumour-causing mutations may be detectable in circulating DNA from patients with early-stage cancers or with pre-cancerous tumours", says Dr Miguel Martins, a programme leader at the MRC Toxicology Unit and lead author of the study. Regarding the importance of follow-up studies, he believes that "Similar studies should now be conducted using mice bearing pre-cancerous lesions in other tissues. This will give us a better idea of whether circulating DNA has potential use for early cancer detection in patients."

Dr Mariana Delfino-Machin, Programme Manager for Cancer at the MRC, which funded the research, added "This is a really promising piece of early-stage research. Lung cancer is incredibly difficult to diagnose at the stage where it can be successfully treated, leading to a poor rate of survival. Developing early detection strategies to improve survival rates is key, and if this can be achieved using only a blood sample it would greatly benefit patients and the NHS. We look forward to the results of the next stages of this research."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Gonorrhea
World Alzheimer's Day 2021 - 'Know Dementia, Know Alzheimer's
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Lung Biopsy Lung Cancer Thalassemia Cancer and Homeopathy Undescended Testicles Cancer Facts Asbestosis Cancer Tattoos A Body Art Varicocele 

Recommended Reading
Lung Cancer
Lung cancer is a malignant tumor in the lung tissues. Smoking is the main cause of lung cancer with ...
Lung Cancer Screening
Lung cancer accounts for nearly 1.3 million deaths annually worldwide. Lung cancer screening can ......
Quiz on Lung Cancer (Advance)
Lung cancer, like other cancers, is a dreaded condition responsible for a number of deaths in ......
New Promise in Targeting Specific Ovarian and Lung Cancers
Shared genetic marker offers new promise in targeting specific ovarian and lung cancers. The drug .....
Asbestosis
Asbestosis is a chronic inflammatory lung disease that occurs due to long term exposure to asbestos ...
Lung Biopsy
The procedure by which tissue samples are obtained from the lung is known as lung biopsy. The biopsy...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...
Thalassemia
Thalassemia is an inherited blood disorder passed on through parental genes causing the body to prod...
Undescended Testicles
An undescended testicle / testis is one that has not descended into the scrotal sac before birth. It...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use