New study identifies the changes that occur in otherwise normal looking brain neurons, with the particular impact forces experienced during head trauma. The findings of the study are published in the Journal of Synchrotron Radiation.
Traumatic brain injury, or TBI, is often referred to as the "invisible injury" - while on the surface everything seems normal with brain structure, symptoms may present themselves in the behavior of the injured and cannot be explained.
According to the Centers for Disease Control and Prevention, about 2.8 million TBI-related emergency department (ED) visits, hospitalizations and deaths occurred in the United States in 2013 alone. Every day, 153 people in the United States die from injuries that include TBI.
As a result of this work, researchers have a better understanding of what kind of experience, or injury, leads to what kind of damage in the myelin - helping to visualize injuries based on the smallest force necessary to cause it. This information may be critical to knowing when someone has an injury after an accident but before symptoms emerge, and helps supports the decision of when and how to treat them.
"Through this research, we've been able to detect specific changes that have never been measured before," said Joseph Orgel, professor of biology and biomedical engineering, Illinois Institute of Technology. "While more research is needed to develop ways to treat these injuries, identifying the crux of the problem the impacts that specific forces have on the brain is an important first step in TBI detection, treatment, and prevention."
The project was supported by grants from ARL and National Institute of General Medical Sciences of the National Institutes of Health.
"Our study examines the initial stage of neural damage with greater sensitivity than previously possible, allowing for the determination of a robust relationship between force and damage," said Ashley Eidsmore, ARL electrical engineer and TBI researcher. "These findings and developed methods will aid in the future development of prophylactic methods, including improved soldier protection, targeted surgery, and medication. ARL's partnership with the Illinois Institute of Technology and Argonne National Laboratory was critical to achieving this advancement in brain injury science."