About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Side Effects of Chemotherapy Could be Cut Down by Fresh Discovery

by Nancy Needhima on March 13, 2012 at 11:06 PM
Font : A-A+

Side Effects of Chemotherapy Could be Cut Down by Fresh Discovery

The structure of a key molecule that can transport chemotherapy and anti-viral drugs into cells, which could help to craft more potent drugs with fewer effects to healthy tissue, has been determined by scientists.

The transporter molecule, called a concentrative nucleoside transporter, works by moving nucleosides, the building blocks of DNA and RNA, from the outside to the inside of cells.

Advertisement

"Knowing the structure and properties of the transporter molecule may be the key to changing the way that some chemotherapies, for example, could work in the body to prevent tumor growth," Seok-Yong Lee, senior author of the study from Duke University, said.

The transporter molecule also transports nucleoside-like chemo drugs through cell membranes. Once inside the cells, the nucleoside-like drugs are modified into nucleotides that are incorporated into DNA in ways that prevent tumour cells from dividing and functioning.
Advertisement

"We discovered the structure of the transporter molecule, and now we believe it is possible to improve nucleoside drugs to be better recognized by a particular form of the transporter molecule that resides in certain types of tissue.

"Now we know the transporter molecule has three forms, which recognize different drugs and reside in different tissues," Lee said.

The team determined the chemical and physical principles a transporter molecule uses to recognize the nucleosides, "so if you can improve the interactions between the transporter and the drug, you won't need as much of the drug to get it into the tumor cells efficiently," Lee said.

"Knowing the shape of the transporters will let scientists design drugs that are recognized well by this transporter," Lee said.

Since the drugs enter healthy cells as well as tumor cells, giving a lower dose of drug that targets tumour tissue would be the best scenario, said Lee, who is also a member of the Duke Ion Channel Research Unit.

"Healthy cells don't divide as often as tumour cells, so lowering the amount of drug given overall would be an effective approach to killing tumours while protecting patients," Lee said.

The researchers studied transporter molecules from Vibrio cholera, a comma-shaped bacterium. The bacterial transporter serves as a good model system for studying human transporters because they share similar amino acid sequences.

They found that both the human and bacterial transporter use a sodium gradient to import nucleosides and drugs into the cells.

The study has been published in Nature online.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
January is the Thyroid Awareness Month in 2022
Menstrual Disorders
Coffee May Help You Fight Endometrial Cancer
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Chronic Lymphocytic Leukemia Hodgkins Lymphoma Non-Hodgkins Lymphoma Chemotherapy Chemotherapy Drugs Peritoneal Cancer Rhabdomyosarcoma Male Breast Cancer Tumor Lysis Syndrome Neutropenic Sepsis 

Recommended Reading
Chemotherapy
'Chemo' means medicine or 'drug'; 'therapy' means 'treatment'. Chemotherapy refers to the use of .....
Chemotherapy Drugs
Chemotherapy drugs perform like 'magic bullets' to destroy cancer cells in the body....
Common Anti-viral Drug Holds Promise to Treat Cancer
A common anti-viral drug called ribavirin may prove to be beneficial in the treatment of cancer ......
Chemotherapy may Not be Necessary in All Patients Post-Hydatidiform Mole Evacuation
Patients with a high hCG level 6 months post-hydatidiform mole evacuation are advised chemotherapy. ...
Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia (CLL) is one of the most common types of adult leukemia and is consider...
Hodgkins Lymphoma
Hodgkins lymphoma or Hodgkins disease has the distinction of being the first cancer to be cured by c...
Male Breast Cancer
Most cases of male breast cancer are diagnosed between the ages of 60 and 70 years. Treatment of mal...
Neutropenic Sepsis
Neutropenic sepsis is a potentially life-threatening condition when a patient with low neutrophil co...
Non-Hodgkins Lymphoma
Non Hodgkins Lymphoma is a cancer that affects the lymph tissues. It is made up of a wide array of ....
Peritoneal Cancer
Peritoneal cancer is a rare cancer that develops in the peritoneum. Peritoneal cancers may be primar...
Rhabdomyosarcoma
Rhabdomyosarcoma is a rare type of cancer affecting the striated muscles. It mostly occurs in ......
Tumor Lysis Syndrome
Tumor lysis syndrome is a collection of metabolic abnormalities due to the tumor cell lysis in patie...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)