About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Severe Heart Attack Damage Limited By Hydrogen Sulfide

by VR Sreeraman on September 23, 2007 at 2:27 PM
Font : A-A+

Severe Heart Attack Damage Limited By Hydrogen Sulfide

Administering hydrogen sulfide (H2S) directly into the heart during a simulated heart attack significantly reduces the tissue and cell damage often seen in oxygen-starved organs, according to a new study from researchers at the University of Alabama at Birmingham.

H2S boosts post-heart-attack function by helping to minimize reperfusion injury, an unwanted side effect of restoring blood flow swiftly to hearts suffering from low oxygen, the study authors said.

Advertisement

In testing on mice, the H2S injection led to a 72 percent reduction in the amount of severe heart-tissue death after restoring normal oxygen and blood flow to mice hearts. The 72 percent reduction compares to a much larger average amount of tissue death in un-treated mice hearts after the same 30 minutes of oxygen deprivation.

Findings on the protective qualities of H2S have broad implications for improving human survival after cardiac arrest, heart transplant and trauma in general, said David Kraus, Ph.D., a UAB associate professor in the Departments of Environmental Health Sciences and Biology and co-author on the new study.
Advertisement

"One of the most damaging biological stresses on the heart and other organs from trauma or transplantation is the rapid change in oxygen levels," Kraus said. "First there's a drop, which elicits a dramatic cellular adjustment to survive low oxygen, and then a rapid rise caused by resuscitation.

"H2S as an internal bodily signal appears to serve as an important protective mechanism during the stress of low oxygen availability," he said.

The study was published Sept. 18 in the online Early Edition of the journal Proceedings of the National Academy of Sciences. The UAB researchers worked with a team led by David Lefer, Ph.D. from the Albert Einstein College of Medicine in Bronx, N.Y.

The tests were done by injecting H2S directly into the hearts of mice who had been anesthetized for surgery, and whose left ventricular artery had been clamped for 30 minutes to simulate a heart attack.

In addition to a decrease in heart-tissue death, H2S-treated mice hearts showed a 35 percent drop in blood-protein levels that signal myocardial damage, and a 26 percent drop in heart-tissue markers of inflammation when compared to un-treated mice hearts.

Furthermore, by isolating mitochondria from the H2S-treated mice, the authors confirmed that heart-cell functional integrity had been preserved. Recent reports from other researchers demonstrate that inhaled H2S can induce a fully reversible "suspended animation" state in animals.

Kraus said it follows that H2S could be used to place organs into "suspended animation" before surgery or during medical transport until normal oxygen and blood flow is restored. Also, by augmenting internal H2S production in the body, perhaps through diet, people may reduce their risks of cardiovascular disease, chronic oxidative cell damage and other illnesses, Kraus said.

H2S is normally considered a toxic, flammable gas that is responsible for the foul odor of rotten eggs. But in the UAB study it was carefully formulated into a low concentration saline-type solution.

Source: Newswise
SRM/S
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
How to Battle Boredom during COVID
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Chest Pain Cardiac Catheterization Heart Attack Diet Lifestyle and Heart Disease Coronary Artery Bypass Grafting Stress and the Gender Divide Heart Attack Facts Heart Heart Attack- Lifestyle Risks Healthy Heart 

Recommended Reading
Heart Attack
Heart attack is the death of the heart muscle due to loss of blood supply. Heart disease is the ......
Yoga And Heart
The various diseases of the heart can be effectively cured through yogic therapy and heart health .....
Heart Attack - Animation
Animation of Heart Attack symptoms. Heart attack is caused due to ischemia of the heart muscles ......
Cardiac Catheterization
Cardiac catheterization is a radiological procedure for both diagnosis and treatment of heart condit...
Chest Pain
Ask any one who has experienced intense chest pain and they will vouch for the fact that it was the ...
Coronary Artery Bypass Grafting
Coronary artery bypass grafting (CABG) or heart bypass surgery is an open heart surgery to relieve t...
Heart Attack- Lifestyle risks
Heart attack is the death of the heart muscle due to loss of blood supply. Simple guidelines to avoi...
Stress and the Gender Divide
Stress has become entwined in the current lifestyle of a young working couple and has resulted in th...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use