Groundwork for New Therapies Against Sepsis
Septic shock comprises a subset of sepsis in which underlying circulatory and cellular metabolism abnormalities are severe enough to increase the risk of death.
Septic shock comprises a subset of sepsis in which underlying circulatory and cellular metabolism abnormalities are severe enough to increase the risk of death.
‘Haptoglobin-based therapies could potentially be used to treat HMGB1-mediated inflammatory diseases such as sepsis.’
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Treatment of mice with the protein haptoglobin resulted in removal of free hemoglobin as well as the protein HMGB1, which had not been previously known to interact with haptoglobin, but is a known mediator of inflammation. Yang and colleagues demonstrated that immune cells known as macrophages removed haptoglobin/hemoglobin complexes as well as haptoglobin/HMGB1 complexes, thereby preventing these complexes from causing tissue damage.
These findings suggest that haptoglobin-based therapies could potentially be used to treat HMGB1-mediated inflammatory diseases such as sepsis.
Researchers Present New Definitions for Sepsis and Septic Shock
Researchers have presented new definitions and clinical criteria for sepsis and septic shock at the Society of Critical Care Medicine's (SCCM).
Researchers have presented new definitions and clinical criteria for sepsis and septic shock at the Society of Critical Care Medicine's (SCCM).
Baby Boy Succumbs to Sepsis Within 30 Hours of Birth in the UK
Sepsis is the body's critical response to infection which can lead to tissue damage, organ failure, and death.
Sepsis is the body's critical response to infection which can lead to tissue damage, organ failure, and death.
Researchers Identify Gene That Triggers Sepsis, Opens Door for New Treatment
Sepsis occurs when molecules on the surface of some bacteria infiltrate cells, triggering an immune response that causes the cells to self-destruct.
Sepsis occurs when molecules on the surface of some bacteria infiltrate cells, triggering an immune response that causes the cells to self-destruct.
