About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Senescent Cells Linked To Atherosclerosis Progression

by Bidita Debnath on October 29, 2016 at 2:29 AM
Font : A-A+

 Senescent Cells Linked To Atherosclerosis Progression

Atherosclerosis is a disease in which arteries narrow due to plaques, which can lead to heart attacks and strokes -- both of which are leading causes of death in the U.S.

Now, in a paper published in Science, Mayo Clinic researchers and colleagues show that senescent cells drive plaque formation in animal models of atherosclerosis.

Advertisement


When stressed, healthy cells undergo senescence.

In this process, cells are blocked from growing or dividing. The cells also release bioactive molecules called the senescence-associated secretory phenotype, or SASP. These molecules break down the normal tissue structure. They also attract immune cells that cause local inflammation.
Advertisement

Using three mouse models, the team, led by Mayo Clinic scientist Jan van Deursen, Ph.D., discovered that senescent cells have negative effects at all three stages of the disease process:

Stage 1

Healthy mice on a high-fat diet that promotes atherosclerosis develop plaque-promoting lesions within days. Bennett Childs, Mayo graduate student, the lead author of the study, found that these so-called "fatty streaks" contained many senescent cells. When mice were treated with a drug that selectively eliminates senescent cells, these fatty streaks disappeared within days.

Stage 2

Fatty streaks progress to larger plaques through the recruitment of white blood cells from the circulation. Two molecules present in streaks and plaques, VCAM1 and MCP1, drive this process. Dr. van Deursen and the team discovered that senescent cells are responsible for the production of VCAM1 and MCP1 in plaques. Selective elimination of senescent cells in growing plaques resulted in fewer and smaller plaques.

Stage 3

In advanced disease, plaques become unstable and are at high risk for rupture. That is a major determining factor in acute heart attacks and strokes. At this stage, senescent cells drove plaque growth. Senescent cells also produced enzymes that dissolve the fibrous cap that initially forms around plaques to provide stability. Selective elimination of senescent cells from mature plaques inhibited further growth of plaque and preserved the integrity of the cap structure and, thus, its stability.

Based on their work, the authors conclude that senescent cells are key drivers of plaque formation and maturation.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
World Heart Day in 2022- Use Heart for Every Heart
Anemia among Indian Women and Children Remains a Cause of Concern- National Family Health Survey-5
H1N1 Influenza Prevention in Children: What Parents Need to Know
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cholesterol Parkinsons Disease Surgical Treatment Heart Attack Cholesterol - The Enigma Chemical Atherosclerosis Aortic Dissection Renal Artery Stenosis Cholesteryl Ester Storage Disease Abdominal Aortic Aneurysm Atherectomy 

Most Popular on Medindia

Find a Doctor Find a Hospital Sinopril (2mg) (Lacidipine) The Essence of Yoga Blood Donation - Recipients Color Blindness Calculator Noscaphene (Noscapine) Indian Medical Journals Iron Intake Calculator A-Z Drug Brands in India
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Senescent Cells Linked To Atherosclerosis Progression Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests