Medical therapy remains the more prominent treatment option for those with epilepsy even though surgery is safe and effective for patients with this disorder.
However, a new 26-year study reveals that following epilepsy surgery, nearly half of participants were free of disabling seizures and 80% reported better quality of life than before surgery. Findings from this study—the largest long-term study to date—are now available in Epilepsia, a journal published by Wiley-Blackwell on behalf of the International League Against Epilepsy (ILAE).
More than 50 million individuals worldwide suffer from seizures caused by epilepsy according to a 2001 report by the World Health Organization (WHO). Medical evidence shows that compared with the general population, epilepsy patients have significantly poorer health-related quality of life, higher rates of co-morbidites, and lower rates of employment, marriage, and education levels. Previous studies found that while a majority of those with epilepsy do respond to antiepileptic drugs, over 30% patients are refractory to medical therapy.
To advance understanding of long-term seizure control rates, researchers analyzed data of seizure and quality of life outcomes for 361 patients who underwent epilepsy surgery between 1967 and 1990; Dr. Sidney Goldring, a prominent neurosurgeon and pioneer of epilepsy surgery, performed the procedures. Patients were then surveyed to assess seizure control and quality of life.
Of the 361 patients, 117 completed follow-up interviews for the study and 48% were determined to be free of disabling seizures. On a survey assessing the quality of life for those with epilepsy, 80% of patients reported their overall quality life was better than before the surgery. As the authors expected, surgical complications and mortality following surgery declined over the long-term. No statistically significant association between postoperative complications and long-term seizure control or quality of life outcomes was observed.
"Our findings demonstrate that the benefits of epilepsy surgery are sustained over long time periods," concludes Dr. Smyth. "Increased use of surgical intervention offers patients with epilepsy the possibility of long-term seizure control and improved quality of life."