Results of the PERSPECTIVE trial show one-year outcomes of patients undergoing chronic total occlusion (CTO) percutaneous coronary intervention (PCI) treated with Zotarolimus-Eluting Stents (ZES). The ZES included in the PERSPECTIVE study were manufactured by Medtronic and represent a modern, newer generation drug-eluting stent (DES).
CTO is a complete blockage of one or more coronary arteries that has been present for at least three months and occurs in 20 percent of patients with coronary artery disease
(UVA Health). CTO PCI has become the preferred treatment option for complex, high-risk patients due to improvements in equipment and novel procedural techniques. There is limited data on procedural and long-term safety and efficacy of CTO revascularization applying modern techniques with newer generation DES.
Using Quality Stents May Lead to Best Patient Outcomes
A stent is a small mesh tube that's used to treat narrow arteries. It is placed in an artery as part of a procedure called percutaneous coronary intervention.
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‘Zotarolimus-eluting stents are safe and effective in patients undergoing chronic total occlusion percutaneous coronary intervention.’
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The PERSPECTIVE trial examined procedural, clinical and health status outcomes using contemporary methods and was reviewed by an independent core laboratory and events committee. Among consecutive patients undergoing attempted CTO PCI, procedural and in-hospital clinical outcomes were examined in addition to major adverse cardiac events (MACE) - death, myocardial infarction and target lesion revascularization. In a pre-specified cohort of prospectively followed patients, quality of life was measured at baseline and one-year. A one-year MACE analysis of patients treated with ZES was compared to a pooled analysis of historical DES trials.
The study included 183 patients with successful CTO recanalization and treatment with ZES. Successful guidewire achievement of at least TIMI 2 flow was observed in 93.4 percent of patients. Compared with performance goals from prior CTO DES trials (1-year MACE, 25.2 percent), treatment with ZES was associated with significantly lower occurrence of adverse events (7.6 percent). One-year rates of myocardial infarction and target lesion revascularization were 3.5 percent and 1.7 percent, respectively. Patients reported significant improvement to quality of life from baseline to one-year (Seattle Angina Questionnaire, 72.3 ± 26.3 versus 96.3 ± 10.2).
![3-D-Printed Polymer Stents Grow With Pediatric Patients]( "3-D-Printed Polymer Stents Grow With Pediatric Patients")
Researchers have developed a novel approach to create stents with growth potential and a sufficient degree of plastic deformation.
"Our study is the most comprehensive review of the safety, efficacy and durability of contemporary stent techniques with ZES for a high-lesion, complex patient population," said lead author David Kandzari, MD, Piedmont Heart Institute in Atlanta, GA. "Not only were the success rates favorable but we were also able to demonstrate that patients reported an improved quality of life, which should be considered one of the most important outcomes of any procedure."
The authors of the study note the FDA is currently reviewing this study data for a potential expanded label indication for the ZES (Medtronic).
Source: Eurekalert
3-D-Printed Polymer Stents Grow With Pediatric Patients
Researchers have developed a novel approach to create stents with growth potential and a sufficient degree of plastic deformation.
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"Our study is the most comprehensive review of the safety, efficacy and durability of contemporary stent techniques with ZES for a high-lesion, complex patient population," said lead author David Kandzari, MD, Piedmont Heart Institute in Atlanta, GA. "Not only were the success rates favorable but we were also able to demonstrate that patients reported an improved quality of life, which should be considered one of the most important outcomes of any procedure."
The authors of the study note the FDA is currently reviewing this study data for a potential expanded label indication for the ZES (Medtronic).
Source: Eurekalert
Price Cap On Stents Will Put Patients In Jeopardy
Stent pricing by the government withdraws the technically superior stents, which is going to cost lives.
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Prices of Stents Reduced, Government Informs Delhi HCThe government informed the Delhi High Court that the prices of coronary stents, used to treat narrowed or weakened arteries in patients, have been reduced by 85 percent. | Advertisement
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