About My Health Careers Internship MedBlogs Contact us

Scientists Unveils New Genetic Links to Juvenile Diabetes on World Diabetes Day

by VR Sreeraman on November 15, 2007 at 5:16 PM
Font : A-A+

Scientists Unveils New Genetic Links to Juvenile Diabetes on World Diabetes Day

Scientists on Wednesday said they had uncovered two more genetic links to juvenile diabetes as the United Nations backed World Diabetes Day to place a spotlight on this fast-growing form of the disease.

In research published in the British journal Nature, experts pointed the finger at variants in two genes, HLA-DQB1 and HLA-DRB1, as boosting the risk of Type 1 diabetes.


The genes are located in a gene-rich cluster on Chromosome 6 that is already implicated in autoimmune diseases, the term for disorders in which the body's tissues are attacked by the immune system.

The genes control rogue proteins that apparently play a role in destroying insulin-producing islet cells in the pancreas and in accelerating the disease.

The research, carried out by the Cambridge Institute for Medical Research in Britain, was based on a genomic comparison among 850 pairs of siblings in Britain and the United States.

The results were compared against 4,000 Britons who had Type 1 diabetes or did not have the disease, and then analysed further against 5,000 individuals enrolled in a separate study being conducted by the Wellcome Trust charity.

Other genes previously linked to diabetes are on Chromosomes 1, 2, 16 and 11, but appear to play different roles in unleashing or amplifying this complex disease.

World Diabetes Day was mandated as a UN-backed event by a United Nations resolution last December.

Diabetes affects 246 million people worldwide and is expected to affect some 380 million by 2025, according to figures on the International Diabetes Federation website.

Wednesday's event focused attention on Type 1 diabetes, which typically occurs in childhood and early adolescence and is associated with genetic predisposition.

Incidence of Type 1 diabetes "is rising alarmingly worldwide, at a rate of three percent a year," the Federation says.

Type 2 diabetes, more common, results mainly from an unhealthy diet and inactivity and is becoming epidemic in scale in many developed or fast-developing countries.

Diabetes is a chronic condition in which the body does not produce enough of the hormone insulin, or cannot make proper use of the insulin it does produce, a condition called insulin resistance.

As a result, there are wild fluctuations of glucose in the blood. This can eventually lead to blindness, heart disease, amputations and kidney failure.

Predicting genetic vulnerability to diabetes could offer huge benefits, doctors believe.

In most cases of Type 1 diabetes, many patients are diagnosed too late to save the so-called beta cells that produce the insulin.

There is no cure yet for the disease, but earlier warning can encourage dietary change and swifter glucose control, thus helping to stave off potentially life-threatening complications.

Source: AFP

News A-Z
News Category
What's New on Medindia
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Diabetic Retinopathy Diabetes Diabetic Diet Diabetes - Essentials Diabetes - Self-Monitoring of Blood Glucose (SMBG) Insulin Delivery Devices Genetics and Stem Cells Diabetes and Exercise Stress Relief Through Alternative Medicine Stress and the Gender Divide 

Recommended Reading
World Diabetes Day
Juvenile diabetes or Type 1 Diabetes is an autoimmune disease that results in low insulin ......
A comprehensive article on diabetes - both Type 1 and Type 2 diabetes, including : causes, signs, sy...
Diabetes - Essentials
Diabetes is a metabolic disease caused by insulin deficiency that leads to high blood sugar levels a...
Diabetes - Self-Monitoring of Blood Glucose (SMBG)
Self-Monitoring Of Blood Glucose (SMBG) is one of the greatest advancements in the management of Di...
Diabetes and Exercise
Regular exercise especially in type II diabetes not only helps reduce the sugar but also reduces the...
Diabetic Diet
The diabetic diet most often recommended is high in dietary fiber (especially soluble fiber) and nut...
Diabetic Retinopathy
The term ‘diabetic retinopathy’ refers to changes in the retina which often occur in people with ......
Insulin Delivery Devices
Insulin delivery devices have evolved drastically since their invention in 1922. They are all aimed ...
Stress and the Gender Divide
Stress has become entwined in the current lifestyle of a young working couple and has resulted in th...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use