About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Scientists Reveal The Secret Of Sperm Quality Control

by VR Sreeraman on February 18, 2012 at 2:08 PM
Font : A-A+

 Scientists Reveal The Secret Of Sperm Quality Control

Yale researchers have discovered how the "guardian of the genome" oversees quality control in the production of sperm — and perhaps in many other cells as well.

The research published online Feb. 16 in the journal Current Biology opens up the potential of developing new forms of birth control and fertility treatment — and even new ways to combat many forms of cancer.

Advertisement

Sperm and other cells go through a sort of inspection process triggered by a key regulatory gene, p53, which orders the destruction of cells with damaged DNA.

This ability has earned it the title of "guardian of the genome," and damage to p53 has been implicated in many forms of cancer.

By studying sperm production in mice, "we have identified p53's new boss, which controls p53 in a way that had been hypothesized before but had not been shown in any animal," said Haifan Lin, professor of cell biology and of genetics, director of the Yale Stem Cell Center, and senior author of the paper.
Advertisement

The Yale team found among more than 1,500 micro-RNA molecules involved in many cellular processes, a regulator called Pumilo 1 controls eight that interact with p53 in sperm production. When Pumilo 1 is deleted in mice, sperm production and fertility are reduced because p53 becomes over active and orders the destruction of too many sperm.

The mechanism may play a key role in male fertility, but it could also be implicated in many biological processes because protection of DNA is so fundamental to life, Lin noted.

"This is a crucial gate-keeping mechanism which allows bad cells, but not good cells, to be killed," Lin said. "This same process may be at play in other tissues, such as cancer."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Genetics of Male Infertility Artificial Insemination Varicocele Premature Ejaculation Sex Numbers 

Most Popular on Medindia

Blood - Sugar Chart Iron Intake Calculator Daily Calorie Requirements How to Reduce School Bag Weight - Simple Tips Accident and Trauma Care Drug Interaction Checker Loram (2 mg) (Lorazepam) Hearing Loss Calculator Blood Donation - Recipients Calculate Ideal Weight for Infants
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Scientists Reveal The Secret Of Sperm Quality Control Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests