A research team from Houston Methodist Research Institute, have discovered a set of immune proteins which are capable of facilitating long-lasting immunity against malaria.
The study published in Immunity reported that elevated levels of immune proteins are capable of regulating the immune system within one day of infection is essential for a sustained anti-malarial immunity in mice.
"Nearly half a million people die from malaria every year," said Rongfu Wang, Ph.D., director of the Center for Inflammation & Epigenetics at Houston Methodist Research Institute. "This is in part due to the lack of an effective malaria vaccine and a limited understanding of the body's immune response during infection. We have identified the immune system pathways activated during infection and potential targets for a malaria vaccine."
Current antimalarial drugs vary by country and are not 100 percent protective, according to the World Health Organization (WHO). The Centers for Disease Control reports that the malaria causing parasite, Plasmodium falciparum, has developed resistance to nearly all of the available antimalarial drugs, including chloroquine.
Wang hopes that his team's findings will help researchers understand how lethal malaria blocks type I interferon signaling and how regulating such signaling will aid in the development of effective anti-malaria vaccines for long-lasting malaria protection.