A new study claims that a three-dimensional model of human respiratory tissue can offer an improved platform to measure the impact of chemicals, like those found in cigarette smoke, or other aerosols on the lung.
The tissue model that the researchers assessed is called MucilAir. Traditional lab-based tests use cell lines that do not reflect normal lung structure and physiology, and in some cases have reduced, or loss of, key metabolic processes, the researchers noted.
Diabetes Risk Increases for Women Whose Parents Smoke During Pregnancy
Female fetuses exposed to tobacco smoke may have increased diabetes risk in middle age, reveals a new study.
Advertisement
Consequently, the long-term toxicological response of the cells can differ from what actually happens in humans, the study to be published in Toxicology in Vitro noted.
"The combined weight of evidence from proteomics, gene expression and protein activity demonstrates that the MucilAir system is far better than continuous cell lines for assessing the effect of repeated exposure to inhaled chemicals and toxicants," says Emmanuel Minet, senior scientist at British American Tobacco.
![Jammu & Kashmir Reports Highest Number of Smokers]( "Jammu & Kashmir Reports Highest Number of Smokers")
About 26.6% population of Jammu & Kashmir is using tobacco products, as a result the state has emerged lung cancer capital of India
The scientists assessed the effectiveness of MucilAir by growing human respiratory epithelial cells at the air-liquid interface on nasal cells. The results showed that the cells in the test model remained viable for at least six months, which makes this tissue model suitable for testing the impact of repeated exposures over a prolonged period, as in the case of the typical smoker.
"Our results give clear supporting evidence that MucilAira, has the potential to be used to test not only the effect of acute doses of toxicants and medicines but also the effect of repeated doses over time," the researchers noted.
Source: IANS
Jammu & Kashmir Reports Highest Number of Smokers
About 26.6% population of Jammu & Kashmir is using tobacco products, as a result the state has emerged lung cancer capital of India
Advertisement
The scientists assessed the effectiveness of MucilAir by growing human respiratory epithelial cells at the air-liquid interface on nasal cells. The results showed that the cells in the test model remained viable for at least six months, which makes this tissue model suitable for testing the impact of repeated exposures over a prolonged period, as in the case of the typical smoker.
"Our results give clear supporting evidence that MucilAira, has the potential to be used to test not only the effect of acute doses of toxicants and medicines but also the effect of repeated doses over time," the researchers noted.
Source: IANS
Women in India Smoke and Use Tobacco More Than Men
Oncologists say that tobacco companies advertise their products to women in India and China in such a way that it makes smoking look socially acceptable.
Advertisement
 City Parks in Seattle Soon To Be Smoke FreeSmoking will be banned in all city parks in Seattle to protect people from second-hand smoke and, also to promote cleaner, healthier environment. | Advertisement
|
Advertisement
Recommended Reading
Latest Respiratory Disease News
The global climate crisis is stimulating heat waves to become more frequent causing distress to people with asthma, say experts.
A new study reveals vitamin D3 supplements have encouraging effects for asthma patients. Vitamin D has a positive effect on immune response.
Hospitalization and mortality rates are on the higher side in First Nations communities than comparable populations.
To end TB by 2030, we need to decrease tuberculosis risk factors and reduce NCDs, among other vital steps to strengthen health systems.
Influenza, commonly called the flu, is an acute, contagious, respiratory tract infection, which is caused by one of the influenza viruses