About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Scientists Identify Protein That Helps Cancer Cells to Survive Stressful Conditions

by Kathy Jones on July 8, 2010 at 10:32 PM
Font : A-A+

 Scientists Identify Protein That Helps Cancer Cells to Survive Stressful  Conditions

A novel discovery that could lead to the development of more effective treatments for a number of diseases has been made by scientists.

Researchers at NUI Galway have shown that a protein produced when cells are stressed interacts with a stress sensor allowing cells to survive conditions of intense stress.

Advertisement

Understanding this interaction may help scientists interfere with cancer cells so the cells can no longer survive exposure to stressful conditions.

Healthy cells are not usually under stress, but unhealthy cells, such as cancer cells, are often under considerable stress because they grow rapidly in places where they are not supposed to grow.
Advertisement

When a cell is under these stressful conditions, the stress protein Hsp70 is activated to help the cell.

Professor Afshin Samali, lead author of the study and head of the Department of Biochemistry at NUI Galway, and his team have discovered that under cell stress conditions Hsp70 interacts with a receptor in the cell, activating survival mechanisms and preventing apoptosis, the normal cell death mechanism.

By understanding more about Hsp70 and the way it functions, scientists can learn how to block its function, allowing unhealthy cells to succumb to stress and die.

This could have significant implications in the development of new cancer drugs, which would block the protein to encourage tumor cell death.

In contrast to diseases where cell death is abundant such as Alzheimer's, Parkinson's Disease, and Diabetes, increasing the levels of Hsp70 could potentially be used to help these cells survive stressful conditions.

"Our results have identified a novel protein-protein interaction that helps cancer cells to survive stressful growth conditions. By interfering with this interaction we hope to develop a new class of anticancer drugs. This work was funded by Science Foundation Ireland and will have a significant impact on cancer research and drug design," Samali stated.

The findings are published in the online, open access journal PLoS Biology.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Ways to Manage Stress during COVID-19 Pandemic
Can Adjusting Fatty Acid Intake Improve Mood in Bipolar Disorder Patients?
Insulin Resistance Doubles the Risk of Major Depressive Disorder
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cancer and Homeopathy Parkinsons Disease Surgical Treatment Colorectal Cancer Cancer Facts Cancer Tattoos A Body Art Diet and Nutrition Tips for Athletes Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant Immune Checkpoint Inhibitors for Cancer Treatment 

Recommended Reading
Endometrial Cancer
Cancer of the Endometrium, or the inner lining of the uterus (womb) is called endometrial cancer....
Colorectal Cancer
Colorectal cancer is a cancer that starts in the colon or the rectum. Colorectal cancer is the third...
Common Lifestyle Habits that Cause Diseases
Cigarette smoking, unhealthy diets, overuse of alcohol, and physical inactivity are some of the most...
Diet and Nutrition Tips for Athletes
Athletes can be physically fit by consuming a well balanced nutritious diet, which keeps them mental...
Health Benefits of Dandelion Plant
What is dandelion? Dandelion greens are nutrition powerhouses with a wide range of health benefits. ...
Immune Checkpoint Inhibitors for Cancer Treatment
Immune checkpoint inhibitors are promising drugs to treat a variety of cancers and the FDA has appro...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use