About My Health Careers Internship MedBlogs Contact us

Scientists Identify Potential Therapeutic Target for Treatment-resistant Breast Cancer

by Rajashri on September 24, 2008 at 3:07 PM
Font : A-A+

 Scientists Identify Potential Therapeutic Target for Treatment-resistant Breast Cancer

A potential therapeutic target for the treatment resistant breast cancer has been identified by researchers from Wyeth's Department of Discovery Translational Medicine.

The researchers have revealed that the activation of Src signalling pathway might make breast cancer resistant to treatment.


The team suggested that inhibiting Src signalling while giving standard medical treatment could help overcome the resistance.

"If this finding is confirmed in clinical trials, which are currently being designed, then inhibiting Src signaling while giving standard of care medical treatment might allow us to overcome some aspects of drug resistance in the clinic," said Christina M. Coughlin, M.D., Ph.D., medical director and global medical monitor at Wyeth Pharmaceuticals, who lead this research in Wyeth's Department of Discovery Translational Medicine.

The identification of genetically altered pathways in human tumours, and their subsequent inhibition, has become a major treatment strategy in many cancers.

Coughlin said researchers suspected that some part of its pathway, either downstream or upstream, might be driving tumour development and treatment resistance.

During the study, the researchers performed quantitative tissue microarray sampling among almost 650 patient samples to analyze for the expression of markers of the Src pathway.

They identified subsets of patients with high Src activation who expressed low levels of estrogen receptor, progesterone receptor and HER2, also known as triple negative breast cancer, as well as subsets expressing the estrogen or progesterone receptors.

These patient sets had lower overall survival associated with expression of Src signalling pathway biomarkers, which suggests that Src pathway activation may have played a role in treatment resistance.

"This gives us all the pieces to the puzzle. This type of cancer signalling pathway study holds the potential to help determine who the appropriate patients are for the newer targeted drugs that we have to treat breast cancer in the absence of genetic signals for a given drug target," Coughlin said.

"We can then translate that information into molecular diagnostics that can be applied within the clinical trials," she added.

The data was presented at the American Association for Cancer Research Molecular Diagnostics in Cancer Therapeutic Development meeting.

Source: ANI

News A-Z
News Category
What's New on Medindia
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Women and Cancer Pagets disease of the breast Mastitis Cancer and Homeopathy Breast Cancer Facts Cancer Facts Cancer Breasts - Structures and Types Breast Lumps Breast Lumps-Screening 

Recommended Reading
Breast Self Examination - Animation
Slides and animation of Breast Self Examination for early detection of breast cancer lumps in ......
Accelerated Irradiation: An Effective Therapy for Breast Cancer
Brief and intensive radiation therapy for early stage breast cancer is equally as effective as the ....
Study Says Breast Cancer Survivors Have High Quality of Life Compared to General Population
Breast cancer patients who have been treated with lumpectomy and radiation have a high level of ......
Breast Lumps
Most breast lumps are caused by hormonal changes in a woman and may not be cancerous. Common causes ...
Breast Lumps-Screening
Breast lumps must never be neglected but instead be subjected to medical examination to rule out ......
Breasts - Structures and Types
Different stages of breast development in women and an in-depth look at the breast/bust and its ......
Mastitis is a common cause of tenderness, swelling and pain in breast, owing to inflammation in the ...
Pagets disease of the breast
A detailed description of the Paget's disease of the breast, characteristic signs and symptoms, dete...
Women and Cancer
Cancer is one of the frequently talked about and most feared disease that falls under the genre of l...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use