A risk gene for schizophrenia, including a potentially causative mutation, using genome-wide association data-mining techniques and independent replications has been discovered by scientists.
Although scientists have earlier used genome-wide association studies to identify genes responsible for diseases that include type 2 diabetes, lung cancer, Parkinson's disease and rheumatoid, the same approach was not as successful for the study of schizophrenia.
Schizophrenia
Schizophrenia is a mental disorder characterized by symptoms of thought, behavior and social problems.
Advertisement
Xiangning Chen, and Kenneth S. Kendler, M.D. led the research, both are professor of psychiatry and human and molecular genetics in the Virginia Institute for Psychiatric and Behavioral Genetics.
Chen mentioned that to obtain consistent results, researchers considered the results from many independent samples.
The team used that approach in this study by first screening two genome-wide association datasets with statistic, genomic, informatic and genetic data and then ranking the top candidate. Chen said that the selected candidates were verified by more than 20 independent samples.
![Brilliant Human Brain - Animation]( "Brilliant Human Brain - Animation")
The most amazing and complex organ in the entire universe, the human brain continues to remain an enigma.
According to the professor, the work is one of the largest genetic studies of schizophrenia and included more than 33,000 participants that identify cardiomyopathy associated 5, or CMYA5, as a risk gene for schizophrenia.
"While its implication for patient care is not clear at this moment, it is fair to say that our paper provides a new target for future research and a practical method to identify other potential risk genes. The findings are one of the most consistent findings in recent literature," he concluded.
The study has been reported in the September issue of the journal Molecular Psychiatry.
Source: ANI
The team used that approach in this study by first screening two genome-wide association datasets with statistic, genomic, informatic and genetic data and then ranking the top candidate. Chen said that the selected candidates were verified by more than 20 independent samples.
Brilliant Human Brain - Animation
The most amazing and complex organ in the entire universe, the human brain continues to remain an enigma.
Advertisement
According to the professor, the work is one of the largest genetic studies of schizophrenia and included more than 33,000 participants that identify cardiomyopathy associated 5, or CMYA5, as a risk gene for schizophrenia.
"While its implication for patient care is not clear at this moment, it is fair to say that our paper provides a new target for future research and a practical method to identify other potential risk genes. The findings are one of the most consistent findings in recent literature," he concluded.
The study has been reported in the September issue of the journal Molecular Psychiatry.
Source: ANI
Adolescent Depression
Adolescent depression is an ailment that occurs during the teenage characterized by persistent melancholy, disappointment and loss of self-esteem.
Advertisement
Advertisement
|
Advertisement
Recommended Reading
Latest Mental Health News
Individuals who have abnormal protein deposits in their brains and also experience more severe sleep apnea are more likely to have smaller volumes in a specific area of the brain.
Researchers examined the impact of having vulnerable friends on victimized and depressed adolescents, in a recently published study in Child Development.
A recent research suggests that the prevalence of major depressive disorder (MDD) patients with activated immune systems may surpass prior estimates.
Consuming flavanol-rich foods like tea, chia seeds, dark chocolate and apples may prevent age-related memory loss, says a new study.
Schizophrenia-related behaviors were induced in mice through the administration of anti-NRXN1α autoantibodies taken from schizophrenia patients.