About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Scientists Identify How Humans And Mice Differ In Treating Allergies

by Aruna on August 13, 2009 at 8:25 AM
Font : A-A+

Scientists Identify How Humans And Mice Differ In Treating Allergies

Scientists have identified the reason that humans and rodents respond differently to a molecule that is being developed to treat allergic diseases.

The research was done by Edith Hessel and colleagues, at Dynavax Technologies Corporation, Berkeley.

Advertisement

Molecules that trigger the protein TLR9 are being developed as a potential therapeutic for allergic diseases. While they have been shown to be safe and well-tolerated when inhaled by people, they cause severe lung inflammation and toxicity when inhaled by rodents. In the study, the toxicity of one of the molecules under development was found to depend on TLR9 and the soluble immune molecule TNF-alpha in mice. Importantly, TLR9 is expressed on many immune cell types in the mouse (monocyte/macrophage cells, B cells, and pDCs) and only on B cells and pDCs in humans. The toxicity in mice was found to be independent of B cells and pDCs, meaning that other immune cells expressing TLR9 were responsible for TNF-alpha production. As human TLR9-expressing cells did not produce TNF-alpha in response to stimulation by the molecules under development, the authors conclude that the differential pattern of TLR9 expression is important in determining the nontoxicity of molecules that target TLR9 in humans and that toxicity in rodents is a result of TNF-alpha production.

Source: Eurekalert
ARU
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Are Menopause Symptoms Troubling You?: Try these Options
Vaccination  And Counter  Measures Against  Monkeypox
Indian Railways Special Concession on Health Grounds
View all
News Archive
Date
Category
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

Most Popular on Medindia

Drug Side Effects Calculator A-Z Drug Brands in India Pregnancy Confirmation Calculator Blood - Sugar Chart Noscaphene (Noscapine) Vent Forte (Theophylline) Iron Intake Calculator Accident and Trauma Care Blood Pressure Calculator Indian Medical Journals

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE