About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Scientists Identify Genetic Key to Breast Cancer's Ability to Survive and Spread

by Rajashri on July 9, 2009 at 8:05 PM
Font : A-A+

 Scientists Identify Genetic Key to Breast Cancer's Ability to Survive and Spread

A genetic function behind breast cancer cells' ability to survive and spread to the bone years after treatment has been administered has been identified by scientists.

Led by investigators at Memorial Sloan-Kettering Cancer Center (MSKCC), the study comes as scientists are looking for therapies to target this survival capacity and force the death of latent breast cancer cells before they get a chance to metastasize, or spread - a problem that accounts for a majority of breast cancer-related deaths.

Advertisement

The researchers used gene-expression profiling techniques, and found that breast cancer cells that infiltrate the bone marrow could survive over time, if they contained the gene product Src.

Src has known effects on cell mobility, invasion, and survival.

By genetically disabling Src activity in human breast cancer cells, it was possible to inhibit these cells from surviving in the bone marrow and forming metastases in mice.
Advertisement

The researchers also saw that treatment with the drug dasatinib inhibits the formation of bone metastasis by human breast cancer cells inoculated into mice.

"Our results should encourage oncologists to consider the study of Src inhibitors to attack reservoirs of disseminated, latent cancer cells and prevent metastasis in breast cancer patients after their tumour has been removed," said the study's senior author, Dr. Joan Massague.

The research has been published in the journal Cancer Cell.

Source: ANI
RAS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test your Knowledge on Heart Transplantation
Test Your Knowledge on Lung Transplantation
Baldness can be Cured and Prevented: let us see How!
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Women and Cancer Breast Biopsy Mastitis Genetics and Stem Cells Cancer Breasts - Structures and Types Breast Lumps Breast Lumps-Screening Breast Cancer Breast Cancer - Prevention and Management with Lifestyle Changes 

Most Popular on Medindia

Blood Donation - Recipients Indian Medical Journals Loram (2 mg) (Lorazepam) Drug Interaction Checker Noscaphene (Noscapine) Blood - Sugar Chart Sanatogen Accident and Trauma Care How to Reduce School Bag Weight - Simple Tips Pregnancy Confirmation Calculator
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use