Scientists Find That Key Protein May Not Really Have A Role In Heart Disease

by Tanya Thomas on July 4, 2009 at 11:12 AM

 Scientists Find That Key Protein May Not Really Have A Role In Heart Disease
A new study has found that C-reactive protein may actually not have a role in causing heart disease. However, it has been an enticing target for scientists working on new treatments for coronary heart disease.

Coronary heart disease is the leading cause of death worldwide. The progression of the disease from early to later, sometimes fatal, stages involves inflammation.

There is strong interest in measuring levels of C-reactive protein in a patient's blood, because it is a marker of inflammation.

Although previous studies have shown that it is a risk indicator, scientists are still not clear whether C-reactive protein causes coronary heart disease.

During the study, the team led by Imperial College London looked at the genes that control C-reactive protein levels in blood and their effect on the risk of coronary heart disease.

Variations in the gene that codes for C-reactive protein were not associated with risk of coronary heart disease.

The authors say that the study has identified genetic variations in three other genes associated with C-reactive protein, which may also be associated with a person's risk of coronary heart disease.

"Some researchers thought C-reactive protein would be a good molecule to target, as raised levels of this protein in the blood are associated with increased risk of coronary heart disease," said Professor Paul Elliott, lead author of the paper, from the Department of Epidemiology and Public Health at Imperial College London.

"However our research suggests that the association may not be causal, so attempts to target this protein to reduce the risk of the disease are unlikely to be fruitful.

"We have also discovered new genetic variations that are associated with coronary heart disease.

If confirmed in other studies, these might give clues to identify new targets to treat the disease," added Elliott.

The study appears in the Journal of the American Medical Association (JAMA).

Source: ANI

News A-Z
News Category
What's New on Medindia
Stroop Effect
Plant-Based Diet may Reduce the Risk of COVID-19
Lower Respiratory Tract Infections Linked to Obstructive Sleep Apnea in Children
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cardiac Catheterization Heart Attack Air travel: To fly or not to fly Diet Lifestyle and Heart Disease Silent Killer Diseases Heart Healthy Heart Statins Mitral Valve Prolapse Aortic Valve Stenosis 

Recommended Reading
Congenital Heart Disease
Heart diseases that are present at birth are called " Congenital heart diseases"....
Diet, Lifestyle and Heart Disease
The correlation between diet, lifestyle and heart disease. The importance of balanced diet life ......
Mitral Valve Stenosis And Mitral Valve Replacement
Mitral valve replacement is a surgical heart procedure to correct either the narrowing (stenosis) .....
Air travel: To fly or not to fly
Air travel is for everyone, even those with medical conditions....
Aortic Valve Stenosis
Aortic valve Stenosis is an abnormal narrowing of the c valve. Symptoms include angina, and that of ...
Cardiac Catheterization
Cardiac catheterization is a radiological procedure for both diagnosis and treatment of heart condit...
Heart Attack
Heart attack is the death of the heart muscle due to loss of blood supply. Heart disease is the lead...
Mitral Valve Prolapse
Mitral Valve Prolapse is a relatively common condition and causes leakage of blood through the valve...
Statins are new wonder drugs that are proving to be efficacious, not merely in relieving symptoms bu...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use