In schizophrenia, there is an alteration in brain-derived neurotrophic factor (BDNF) and neuregulin 1 (NRG1), which are important genes and signaling pathways.
To date, no studies have reported magnetic resonance spectroscopy in a rat model of schi-zophrenia induced by early growth response protein 3 gene (Egr3) transfection. Prof. Guolin Ma and colleagues from China-Japan Friendship Hospital, China used multivoxel proton magnetic resonance spectroscopy to study neuronal metabolite content in rats transfected with the Egr3 gene as a putative model of schizophrenia. 3.0 T proton magnetic resonance spectroscopy of in vivo brain tissues showed metabolic abnormalities in hippocampal and thalamic neurons of growth response protein 3 transfected rats. These findings, published in the Neural Regeneration Research (Vol. 8, No. 26, 2013), provide imaging evidence that may be useful in the early diagnosis and pathogenesis of schizophrenia.