About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Scientists Examine How Bacteria Infect Their Living Hosts

by Aruna on July 31, 2009 at 11:02 AM
Font : A-A+

Scientists Examine How Bacteria Infect Their Living Hosts

University of Bath and University of Exeter scientists have come up with a novel technique to make movies of bacteria infecting their living hosts.

The researchers claim that, to date, most studies of bacterial infection have been done after the death of the infected organism, and that they are the first scientists who have been successful in following the progress of infection in real-time with living organisms.

Advertisement

They used developing fruit fly embryos as a model organism, injecting fluorescently tagged bacteria into the embryos and observing their interaction with the insect's immune system using time-lapse confocal microscopy.

The team say that they can also tag individual bacterial proteins to follow their movement, and determine their specific roles in the infection process.
Advertisement

The researchers are hoping to use this system in the future with human pathogens, such as Listeria and Trypanosomes.

According to them, observing how these bacteria interact with the immune system may prove helpful in gaining a better understanding of how they cause an infection, and eventually lead to better antibacterial treatments.

Dr. Will Wood, Research Fellow in the Department of Biology and Biochemistry at the University of Bath, said: "Cells often behave very differently once they have been taken out of their natural environment and cultured in a petri dish. In the body, immune surveillance cells such as hemocytes (or macrophages in vertebrates) are exposed to a battery of signals from different sources. The cells integrate these signals and react to them accordingly."

Dr. Wood added: "Once these cells are removed from this complex environment and cultured in a petri dish these signals are lost. Therefore it is really important to study whole organisms to fully understand how bacteria interact with their host."

Dr. Nick Waterfield, co-author on the study and Research Officer at the University of Bath, said: "To be able to film the microscopic battle between single bacterial cells and immune cells in a whole animal and in real time is astounding. It will ultimately allow us to properly understand the dynamic nature of the infection process."

Professor Richard Ffrench-Constant, Professor of Molecular Natural History at the University of Exeter, added: "For the first time this allows us to actually examine infection in real time in a real animal - it's a major advance!"

Funded by the Wellcome Trust and the Biotechnology and Biological Sciences Research Council, the study has been published in PLoS Pathogens.

Source: ANI
ARU
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test your Knowledge on Heart Transplantation
Test Your Knowledge on Lung Transplantation
Baldness can be Cured and Prevented: let us see How!
View all
Recommended Reading
News Archive
Date
Category
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Shigellosis MRSA - The Super Bug Food Safety for Health Antibiotics 

Most Popular on Medindia

Nutam (400mg) (Piracetam) Drug - Food Interactions Loram (2 mg) (Lorazepam) How to Reduce School Bag Weight - Simple Tips Daily Calorie Requirements The Essence of Yoga Indian Medical Journals Drug Interaction Checker Blood - Sugar Chart Drug Side Effects Calculator
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT ONLINE WITH A DOCTOR