About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Scientists Discover Emergency Response System For Blood Formation

by Shirley Johanna on November 19, 2015 at 4:23 PM
Font : A-A+

Scientists Discover Emergency Response System For Blood Formation

The body's response during times of emergency when it needs more blood cells has been identified by scientists at the Children's Medical Center Research Institute at UT Southwestern (CRI).

In a study published in Nature, researchers report that when tissue damage occurs, in times of excessive bleeding, or during pregnancy, a secondary, emergency blood-formation system is activated in the spleen.

Advertisement


"Hematopoietic, or blood-forming, stem cells reside mainly in the bone marrow, and most new blood cell formation occurs within the bone marrow under normal circumstances. But when there is hematopoietic stress, blood cell formation expands to the spleen," said Dr. Sean Morrison, CRI Director and Mary McDermott Cook Chair in Pediatric Genetics at UT Southwestern Medical Center.

"Blood-forming stem cells migrate from the bone marrow to the spleen, which becomes a hematopoietic organ where blood formation then occurs."

Normally, there are very few blood-forming stem cells in the spleen. But the cells that create the supporting environment for these stem cells are present in the spleen, ready to respond during times of hematopoietic stress and to receive an influx of blood-forming stem cells from the bone marrow.
Advertisement

In characterizing the microenvironment, or niche, which supports blood formation in the spleen, the CRI research team used mouse models to examine the expression patterns of two known niche cell factors, stem cell factor (SCF) and CXCL12.

The researchers found that the blood-forming microenvironment in the spleen is found near sinusoidal blood vessels and is created by endothelial cells and perivascular stromal cells - just like the microenvironment in the bone marrow.

"Under emergency conditions, the endothelial cells and perivascular stromal cells that reside in the spleen are induced to proliferate, so they can sustain all the new blood-forming stem cells that migrate into the spleen," said Dr. Morrison, who is also a CPRIT Scholar in Cancer Research and a Howard Hughes Medical Institute Investigator.

"We determined that this process in the spleen is physiologically important for responding to hematopoietic stress; without it, the mice we studied could not maintain normal blood cell counts during pregnancy or quickly regenerate blood cell counts after bleeding or chemotherapy."

Based on this new information about the spleen's emergency backup role for blood cell formation, therapeutic interventions could be developed in the future to enhance blood formation following chemotherapy or bone marrow transplantation and thus accelerate the recovery of blood cell counts.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test Your Knowledge About Chromosomes?
Eating During Sunlight Hours Minimizes Mood Vulnerabilities
Know More About the Digestive System
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Thalassemia Emergency Alarming Facts about Road Traffic Accidents Road Traffic Accidents and Road Safety Women More Prone to Road Rage Blood in Stools - Symptom Evaluation Bombay Blood Group 

Most Popular on Medindia

Pregnancy Confirmation Calculator Drug - Food Interactions Loram (2 mg) (Lorazepam) Blood Pressure Calculator Blood - Sugar Chart Hearing Loss Calculator Blood Donation - Recipients Selfie Addiction Calculator Post-Nasal Drip Diaphragmatic Hernia
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Scientists Discover Emergency Response System For Blood Formation Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests