About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Scientists Discover Cancer Cells' Achilles' Heel

by Sheela Philomena on April 27, 2013 at 11:37 AM
Font : A-A+

 Scientists Discover Cancer Cells' Achilles' Heel

Scientists have identified why a particular cancer drug is so effective at killing cells.

Professor Daniel Davis and his team used high quality video imaging to investigate why the drug rituximab is so effective at killing cancerous B cells.

Advertisement

It is widely used in the treatment of B cell malignancies, such as lymphoma and leukaemia - as well as in autoimmune diseases like rheumatoid arthritis.

Using high-powered laser-based microscopes, researchers made videos of the process by which rituximab binds to a diseased cell and then attracts white blood cells known as natural killer (NK) cells to attack.
Advertisement

They discovered that rituximab tended to stick to one side of the cancer cell, forming a cap and drawing a number of proteins over to that side. It effectively created a front and back to the cell - with a cluster of protein molecules massed on one side.

But what surprised the scientists most was how this changed the effectiveness of natural killer cells in destroying these diseased cells. When the NK cell latched onto the rituximab cap on the B cell, it had an 80 percent success rate at killing the cell. In contrast, when the B cell lacked this cluster of proteins on one side, it was killed only 40 percent of the time.

"These results were really unexpected. It was only possible for us to unravel the mystery of why this drug was so effective, through the use of video microscopy. By watching what happened within the cells we could clearly identify just why rituximab is such an effective drug - because it tended to reorganise the cancerous cell and make it especially prone to being killed," Professor Davis said.

He added: "What our findings demonstrate is that this ability to polarise a cell by moving proteins within it should be taken into consideration when new antibodies are being tested as potential treatments for cancer cells. It appears that they can be up to twice as effective if they bind to a cell and reorganise it."

The findings from this study have been published online on the website of the journal Blood.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Sensory Processing Disorder (SPD)
First Dose of COVID-19 Vaccines May Improve Mental Health
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cancer and Homeopathy Cancer Facts Cancer Tattoos A Body Art Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant Immune Checkpoint Inhibitors for Cancer Treatment Non-Communicable Diseases 

Recommended Reading
Leukemia
Encyclopedia section of medindia gives general information about Leukemia...
Hodgkins Lymphoma
Hodgkins lymphoma or Hodgkins disease has the distinction of being the first cancer to be cured by ....
Leukemia / Blood Cancer
Leukemia is cancer of blood-forming tissues in the body....
Researchers Suggest New Drug Combination Therapy to Treat Leukemia
A new, pre-clinical study by researchers suggests that a novel drug combination could lead to ......
Common Lifestyle Habits that Cause Diseases
Cigarette smoking, unhealthy diets, overuse of alcohol, and physical inactivity are some of the most...
Health Benefits of Dandelion Plant
What is dandelion? Dandelion greens are nutrition powerhouses with a wide range of health benefits. ...
Immune Checkpoint Inhibitors for Cancer Treatment
Immune checkpoint inhibitors are promising drugs to treat a variety of cancers and the FDA has appro...
Non-Communicable Diseases
Non-Communicable Diseases (NCDs) are a group of chronic non-infectious diseases which include Cardio...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use